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Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control. [PDF]

Signal Transduct Target Ther
Wang S, Li W, Wang Z, Yang W, Li E, Xia X, Yan F, Chiu S.   +7 more
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Antiviral immunotoxins: antibody-mediated delivery of gelonin inhibits Pichinde virus replication in vitro

Antiviral Research, 1991
Immunotoxins were produced and evaluated for antiviral activity against Pichinde virus, a member of the family Arenaviridae. Immunoglobulins were conjugated to the ribosome-inactivating protein, gelonin, through a disulfide linkage to form the immunotoxins.
B B, Barnett, N J, Burns, K J, Park, M I, Dawson, M, Kende, R W, Sidwell   +5 more
openaire   +4 more sources

Virion-associated ribosomes are not required for the replication of Pichinde virus

Virology, 1977
Abstract Ribosomes of host cell origin have been isolated from Pichinde virus. A cell mutant with a temperature-sensitive defect in protein synthesis and 60 S ribosomal subunits was employed to study the role of virion-associated ribosomes in the replication of Pichinde virus. Virions carrying the temperature-sensitive ribosomes replicated as well at
W C, Leung, W E, Rawls
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Persistent infection of mice with Pichinde virus associated with failure to thrive

Microbial Pathogenesis, 1995
Intracranial inoculation of neonatal mice of certain inbred strains with Pichinde virus has been found to be fatal, but Balb/c neonates survive such infection. Survival of Balb/c mice after neonatal inoculation was not linked to the major histocompatability complex. Virus was gradually cleared in surviving Balb/c mice but could be detected in the brain
K E, Wright, R, Ahmed, M J, Buchmeier
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Mapping the cytotoxic T-lymphocyte epitopes of Pichinde virus.

2009
One of the aims of this study was to determine whether the glycoproteins of Pichinde virus harbour any cytotoxic T-lymphocyte (CTL) epitopes on the murine haplotypes, H-2$\sp{\rm b}$ and H-2$\sp{\rm d}$ since, on neither of these MHC backgrounds are there any CTL epitopes on the nucleoprotein of this virus.
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Cloning and expression of the glycoproteins of pichinde virus by vaccinia virus.

2009
Pichinde virus (Pic), like the other arenaviruses, possesses two glycoproteins, GP1 and GP2, that are derived by proteolytic cleavage from a precursor molecule, GPC. Within the arenaviruses, GP1 is the most heterogeneous protein, and GP1 of Pic differs from that of the other arenaviruses in having twice as many potential N-linked glycosylation sites ...
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Death after Pichinde Virus Infection in Large and Small Strain 13 Guinea Pigs

Journal of Infectious Diseases, 1993
The lethal events of Pichinide virus infections were studied in large (> 36-week-old), small (4- to 6-week-old), and uninfected strain 13 guinea pigs. Time to death was shorter and the rate of body weight loss greater for large than for small virus-infected guinea pigs.
R C, Schaeffer, M S, Bitrick
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Ribonucleoprotein complexes associated with virions of Pichinde virus and Pichinde virus-infected cells

Medical Microbiology and Immunology, 1986
YOUNG, PR, HOWARD, CR
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Observation of the in situ contracting heart of guinea pigs infected with Pichinde virus

Life Sciences, 1987
The in situ beating hearts from anesthetized control and Pichinde virus-infected strain 13 guinea pigs, between days 7 and 19 postinoculation, were directly observed and video recorded. Although some hearts from Pichinde virus-infected animals were visually depressed and had altered contraction patterns, such a pronounced cardiac dysfunction was not ...
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