Results 1 to 10 of about 11,050 (171)

Structure‐Guided Surface Engineering of an Artificial Metallolyase for Highly Enantioselective Michael Addition

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
X‐ray visualization of copper‐binding modes revealed nonspecific surface metal sites that compromise stereoselectivity. Structure‐guided mutations suppressed background reactivity and enabled precise enantioselective control in the Michael addition, delivering up to 99% ee.
Saito Morikawa, Naoki Saegusa, Ryusei Matsumoto, Yoshitsugu Morita, Nobutaka Fujieda   +4 more
wiley   +1 more source

Impact of Gut Microbiota Metabolites on Serotonin Levels in Irritable Bowel Syndrome

Gut Medicine, Volume 2, Issue 2, Page 98-111, June 2026.
ABSTRACT Gut microbiota and their metabolites have been proposed as possible etiological factors in irritable bowel syndrome (IBS), and studies suggest that IBS is associated with impaired serotonin synthesis and release. Microbial metabolites are produced through biological pathways and enzymatic processes via gut microbiota.
Ning Gao, Yu Liu, Shaoxin Sun, Lulu Bin, Shanshan Li, Tao Yang, Winson Fu Zun Yang, Jiani Wu   +7 more
wiley   +1 more source

Study on Design, Synthesis and Herbicidal Activity of Novel 4-Amino-6-(5-Aryl-Substituted-1-Pyrazolyl)-3-Chloro-5-Fluoro-2-Picolinic Acids

Molecules
6-Aryl-2-picolinic acid herbicides are an important subclass of auxin herbicides, characterized by their good absorption and conductivity, broad weed control spectrum, and excellent herbicidal activity against some resistant weeds.
Huiting Li, Wei Wei, Rongchuan Shi, Yunhan Gou, Xiaofei Li, Chengyang Li, Yiqun Li, Yiming Cao, Shangzhong Liu   +8 more
doaj   +1 more source

Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s):Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers ...
Nematollah Gheibi, Negar Taherkhani, Abolfazl Ahmadi, Kamahldin Haghbeen, Dariush Ilghari   +4 more
doaj  

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Solid–Solid Synthesis, Crystal Structure and Thermal Decomposition of Copper(II) Complex of 2-Picolinic Acid [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2016
The copper(II) complex [Cu(pic)2]·2H2O was synthesized with 2-picolinic acid (Hpic) and copper acetate as reactants by room temperature solid-solid reaction.
Di Li, Guo-Qing Zhong, Qing Zang
doaj  

In vitro activity of 2-pyridinecarboxylic acid against trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus = Atividade in vitro do ácido 2-piridinocarboxílico em tripanossoma do subgênero Schizotrypanum isolado do morcego Phyllostomus hastatus

Acta Scientiarum: Biological Sciences, 2011
The effect of 2-pyridinecarboxylic acid (picolinic acid) on trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus was determined in this study.
Paulo Roberto Ceridóreo Corrêa, Artur da Silveira Pinto, Grácia Divina de Fátima Silva, Sidney Augusto Vieira Filho, Lucienir Pains Duarte, Sueli Fumie Yamada-Ogatta   +5 more
doaj  

Synthesis, Spectral, Magnetic and Thermal Studies of the Complexes of CoII and NiII With Some Bidentate and Tridentate Hydrazone Ligands

E-Journal of Chemistry, 2005
The reaction of Co(NO3)2.6H2O and Ni(NO3)2.6H2O with hydrazones derived from 1-phenyl-3-methyl-4-acyl-5-pyrazolone (where acyl = acetyl, propionyl, butyryl and benzoyl) with 2-picolinic acid hydrazide have been studied and characterized on the basis of ...
Chetan K. Modi, Ashwin S. Patel, Bharat T. Thaker   +2 more
doaj   +1 more source

Highly sensitive quantification of 7α-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS

Journal of Lipid Research, 2007
We describe a highly sensitive and specific method for the quantification of serum 7α-hydroxy-4-cholesten-3-one (C4), which has been used as a biomarker for bile acid biosynthesis.
Akira Honda, Kouwa Yamashita, Mitsuteru Numazawa, Tadashi Ikegami, Mikio Doy, Yasushi Matsuzaki, Hiroshi Miyazaki   +6 more
doaj   +1 more source