Results 21 to 30 of about 11,970 (204)
Preparation and diagnosis of new picolinic acid derivatives
Tikrit Journal of Pure Science, 2023 In this study, a new series of heterocyclic rings derived from picolinic acid was prepared. The quaternary reaction of acid hydrazone with chloroacetyl chloride was intended to obtain the azitidine-2-on ring known as beta-lactam and the preparation of ...
Wameed Raad Abd-allah +1 more
doaj +1 more source
New pyrazolone derivatives, synthesis, characterization, and neuroprotective effect against PTZ- induced neuroinflammation in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): The study was aimed at synthesis of the new derivatives of the pyrazolone nucleus, and their spectroscopic and pharmacological analysis and evaluation.
Madiha Kanwal +7 more
doaj +1 more source
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. [PDF]
PLoS ONE, 2012 Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid.
Antje Blumenthal +8 more
doaj +1 more source
Applied Sciences, 2022 Topography of tungsten should be assured at a minimum through chemical mechanical planarization (CMP) in the metal gate structures (e.g., buried gates, replacement metal gates) and via contact in the middle of line (MOL) process for sub−7 nm ...
Kangchun Lee, Jihoon Seo
doaj +1 more source
Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect. [PDF]
J Child Psychol PsychiatryBackground Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Gustafsson HC +4 more
europepmc +2 more sources
RELAXATION OF ISOLATED AORTA OF THE RABBIT BY PICOLINIC ACIDS [PDF]
British Journal of Pharmacology, 1977 When the isolated thoracic aorta of the rabbit was contracted with prostaglandin F2α, 5‐alkylpicolinic acids produced dose‐dependent relaxations. Picolinic acid, 2,5‐pyridinedicarboxylic acid and 5‐acetylpicolinic acid which do not have the 5‐alkyl residue failed to relax blood vessels.
M, Asano, H, Hidaka
openaire +2 more sources
6-Phosphoryl Picolinic Acids as Europium and Terbium Sensitizers
Inorganic Chemistry, 2011 Three 6-phosphoryl picolinic acid (6PPA) derivatives were synthesized and used as europium and terbium sensitizers. Two of the three ligands (6-diethoxyphosphoryl picolinic acid (Hdeppa) and 6-monoethoxyphosphoryl picofinic acid (H(2)meppa)) are water ...
Chauvin, Anne-Sophie, Andres, Julien
core +3 more sources
A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity [PDF]
Pharmacia, 2021 Thirteen new derivatives of picolinic acid (4–7) were designed and synthesized from the starting parent molecule, picolinic acid. The new compounds were characterized by ATR-FTIR, 1HNMR, and CHNS analysis.
Ali H. Abbas +6 more
doaj +3 more sources
Acta Scientiarum: Biological Sciences, 2011 The effect of 2-pyridinecarboxylic acid (picolinic acid) on trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus was determined in this study. Picolinic acid, at 50 µg mL-1, inhibited epimastigote growth by 99% after 12
Paulo Roberto Ceridório Corrêa +5 more
doaj +1 more source
European Psychiatry, 2021 Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle +4 more
doaj +1 more source