Results 91 to 100 of about 9,317 (205)

Engineering a “muco‐trapping” ACE2‐immunoglobulin hybrid with picomolar affinity as an inhaled, pan‐variant immunotherapy for COVID‐19

Bioengineering & Translational Medicine
Soluble angiotensin‐converting enzyme 2 (ACE2) can act as a decoy molecule that neutralizes severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by blocking spike (S) proteins on virions from binding ACE2 on host cells.
Karthik Tiruthani, Carlos Cruz‐Teran, Jasper F. W. Chan, Alice Ma, Morgan McSweeney, Whitney Wolf, Shoufeng Yuan, Vincent K. M. Poon, Chris C. S. Chan, Lakshmi Botta, Brian Farrer, Ian Stewart, Alison Schaefer, Jasmine Edelstein, Priya Kumar, Harendra Arora, Jeff T. Hutchins, Anthony J. Hickey, Kwok‐Yung Yuen, Samuel K. Lai   +19 more
doaj   +1 more source

Nanomaterial‐Based Inkjet Printing for Electrochemical Sensing

Small, EarlyView.
Inkjet printing provides a digitally controlled, versatile, and highly reproducible method for fabricating and functionalizing sensing devices. This Perspective highlights how homogeneous, material‐efficient deposition enables precise patterning of functional inks and scalable integration of sensors for chemical and biological detection. The discussion
David Panáček, Massimo Urban, Alessandro Silvestri, Ivan Dědek, Martin‐Alex Nalepa, Arben Merkoçi, Maurizio Prato, Michal Otyepka   +7 more
wiley   +1 more source

Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Random hetero oligomers (RHOs) of defined compositions are synthesized and fractionated to identify the chemical design criteria (charge, length, hydrophobicity) required to achieve nanomolar binding to green fluorescent protein, resulting in >100% fluorescence increases.
Darwin C. Gomez, Swarnadeep Seth, Ronnie Mondal, Stephen J. Koehler, Jared G. Baker, Charles Plate, Ian C. Anderson, Mikayla R. Smith, Joey Gloriod, Morgan Gunter, Valerie V. Welborn, Sanket A. Deshmukh, C. Adrian Figg   +12 more
wiley   +2 more sources

Single‐molecule validation and optimised protocols for the use of secondary nanobodies in multiplexed immunoassays

Journal of Microscopy, EarlyView.
Abstract Recently developed secondary nanobodies or single‐domain antibodies present a powerful tool for immunodetection. Unlike traditional antibodies, their monovalence enables pre‐association with primary antibodies prior to sample staining, presenting a straightforward affinity‐based antibody labelling solution.
Rebecca Saleeb, Judi O'Shaughnessy, Ryan Ferguson, Candace T. Adams, Mathew H. Horrocks   +4 more
wiley   +1 more source

Structure-guided development of heterodimer-selective GPCR ligands [PDF]

, 2016
Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for ...
Clark, Tim, Gienger, Marie, Gmeiner, Peter, Hübner, Harald, Kaindl, Jonas, Leeb, Laurin, Möller, Dorothee, Schaab, Carolin, Schellhorn, Tamara   +8 more
core   +1 more source

Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
Frontiers Production Office
doaj   +1 more source

Matrix Metalloproteinases in Periodontal and Peri‐Implant Diseases: Contribution to Their Pathogenesis, Diagnosis, and Treatment

Journal of Periodontal Research, EarlyView.
This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa, Lorne M. Golub, Julie Toby Thomas, Pietro Leone, Sukumaran Anil, Veli‐Jukka Uitto   +5 more
wiley   +1 more source

2016 EMBO Chemical Biology Conference [PDF]

, 2017
From August 31st- September 3rd the biennual EMBO Chemical Biology conference, hosted by the European Molecular Biology Laboratory (EMBL) in Heidelberg took place.
Bantscheff, Beans, Beck, Beer, Bergamini, Blatter, Buntz, Carette, Chatterjee, Chouchani, Chowdhury, Conway, Dittmann, Du, Ferreras, Frank, Gaali, Hackl, Heinis, Holt, Höfer, Jia, Jones, Jung, Kapp, Kollmannsperger, Komor, Labòria, Lechner, Lun, Makley, Mapp, Melo Czekster, Minoshima, Nadler, Niinivehmas, Nikic, Pao, Pianowski, Plass, Prier, Renata, Schoffelen, Sellmyer, Winter, Yamagishi, Zheng   +46 more
core   +2 more sources

Phage Display Derived Antibodies Against Antimicrobial Peptide FsPDF2 Reveal Stress Response in European Beech

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant defensins (PDFs) are cysteine‐rich antimicrobial peptides (AMPs) that are important components of plant immunity. They occur constitutively in various plant tissues but are also upregulated upon stress. Therefore, these molecules are of great interest as markers for the diagnosis of early forest stress response in plants at the molecular
Philip Alexander Heine, Tetyana Nosenko, Sarah Kistner, Kevin Dennis Oliphant, Manuel Hanke‐Uhe, Afsheen Shahid, Bin Hu, Martin Kucklick, Nina Lehmler, Marlies Becker, Nicole Goerke, Janin Korn, Tanja Linke, Doris Meier, Asta Perl, Saskia Polten, Valeska Priess, Dorina Schäckermann, Maren Schubert, Jörg Schumacher, Jana Barbro Winkler, Susanne Engelmann, Heinz Rennenberg, Jörg‐Peter Schnitzler, Stefan Dübel, Michael Hust, Robert Hänsch, David Kaufholdt   +27 more
wiley   +1 more source

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens. [PDF]

, 2015
Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented by the major histocompatibility complex (pMHC) on the surface of professional antigen-presenting cells and infected or malignant cells. The efficiency of T
Alam, Aleksic, Aleksic, Alexander-Miller, Angelov, Artyomov, Atkins, Au-Yeung, Bachmann, Besser, Besser, Black, Boon, Borbulevych, Bos, Boulter, Brahmer, Brentville, Bridgeman, Bullock, Busch, Cameron, Campoli, Carreno, Carreno, Casas, Cebecauer, Chen, Chen, Chervin, Chlewicki, Cole, Corr, Corse, Corse, Coulie, Couzin-Frankel, Cukalac, Davis, Derby, Dolton, Dudley, Dudley, Dunn, Dushek, Dutoit, Dutoit, Dvorak, Dzutsev, Edwards, Engels, Engels, Faroudi, Fivash, Foley, Fonteneau, Fridman, Gallimore, Gannon, Garon, Gill, Gonzalez, Govern, Guillaume, Guy, Haidar, Hebeisen, Hebeisen, Hebeisen, Hodi, Holler, Holler, Holler, Hombrink, Hong, Huang, Huppa, Irving, Janicki, Jiang, Johnson, June, Kalergis, Keane, Kedl, Kersh, Klebanoff, Klein, Knabel, Krogsgaard, Kronig, Kunert, Kurts, Kyewski, La Gruta, Laugel, Li, Linette, Liu, Liu, Lovgren, Malecek, Malherbe, Matsui, McKeithan, McMahan, McMahan, Mellman, Morgan, Morgan, Nauerth, Nauerth, Neudorfer, Overwijk, Pages, Palmer, Palmer, Postow, Price, Pryshchep, Radvanyi, Restifo, Riquelme, Robbins, Robbins, Robbins, Robert, Robert, Romero, Rosenberg, Rosenberg, Rosenberg, Rosette, Salter, Savage, Schmid, Schmidt, Schmidt, Schmitt, Schumacher, Schwartzentruber, Slansky, Speiser, Speiser, Stone, Stone, Sykulev, Tan, Thomas, Tian, Topalian, Trautmann, Turner, Turula, Valitutti, Valitutti, Verdeil, Vigano, Vigano, Wang, Weiss, Wiedemann, Wilde, Wooldridge, Yee, Yee, Yeh, Zeh, Zehn, Zehn, Zehn, Zhao, Zhong, Zhu, Zhu, Zoete, Zoete   +176 more
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