Results 101 to 110 of about 9,317 (205)

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2023
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Pathogen‐reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange

Transfusion, EarlyView.
Abstract Background Therapeutic plasma exchange (TPE) for thrombotic thrombocytopenic purpura (TTP) and auto‐immune disorders involves repeated patient exposure to allogenic plasma with the risk of transfusion‐transmitted infection (TTI).
Florian Tupin, Clarisse Mouriaux, Beatrice Hechler, Kaja Kaastrup, Subra Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

Selection and characterization of a broadly neutralizing class of HCV anti-E2 VH1-69 antibodies.

PLoS Pathogens
Identification and characterization of antibody epitope targets on the hepatitis C virus (HCV) envelope proteins remain crucial for developing an effective vaccine.
Andreas Soerensen, Filip Popovic, Christina Holmboe Olesen, Blanca Lopez Mendez, Brian Lohse, Zhaochun Chen, Patrizia Farci, Robert H Purcell, Harvey J Alter, Lea Klingenberg Barfod, Jens Bukh, Jannick Prentoe   +11 more
doaj   +1 more source

Characterization of a re‐engineered, mesothelin‐targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

Molecular Oncology, 2016
Mesothelin overexpression in lung adenocarcinomas correlates with the presence of activating KRAS mutations and poor prognosis. Hence SS1P, a mesothelin‐targeted immunotoxin, could offer valuable treatment options for these patients, but its use in solid
Frieder Bauss, Martin Lechmann, Ben-Fillippo Krippendorff, Roland Staack, Frank Herting, Matthias Festag, Sabine Imhof-Jung, Friederike Hesse, Marc Pompiati, Gwendlyn Kollmorgen, Rita da Silva Mateus Seidl, Birgit Bossenmaier, Wilma Lau, Christian Schantz, Jan O. Stracke, Ulrich Brinkmann, Masanori Onda, Ira Pastan, Klaus Bosslet, Gerhard Niederfellner   +19 more
doaj   +1 more source

Gadolinium Pollution—A Future Forward Perspective on Human and Environmental Impact

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1660-1670, March 2026.
ABSTRACT The widespread use of gadolinium‐based contrast agents (GBCAs) in magnetic resonance imaging (MRI) has been instrumental in enhancing diagnostic capabilities. However, the potential environmental and human health impacts of gadolinium pollution have become a growing concern.
Makayla R. Long, Nir A. Dayan, Meicai Xu, Wei Liao, Assaf A. Gilad, Mark C. DeLano   +5 more
wiley   +1 more source

Uptake of 3,3',5,5'-tetraiodothyroacetic acid and 3,3',5'-triiodothyronine in cultured rat anterior pituitary cells and their effects on thyrotropin secretion [PDF]

, 1995
We compared the uptake, metabolism, and biological effects of tetraiodothyroacetic acid (Tetrac) and rT3 in anterior pituitary cells with those of T4 and T3. Cells were isolated from adult male Wistar rats and cultured for 3
Docter, R. (Roel), Everts, M.E. (Maria), Hennemann, G. (George), Jong, M. (Marion) de, Krenning, E.P. (Eric), Moerings, E.P.C.M. (Ellis), Tempelaars, A.M., Toor, H. (Hans) van, Visser, T.J. (Theo)   +8 more
core   +1 more source

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu₂ Receptor Agonist

Journal of Medicinal Chemistry
Metabotropic glutamate (Glu) receptors (mGlu receptors) play a key role in modulating excitatory neurotransmission in the central nervous system (CNS). In this study, we report the structure-based design and pharmacological evaluation of densely functionalized, conformationally restricted glutamate analogue (1S,2S,3S)-2-((S)-amino(carboxy)methyl)-3 ...
Liu, Na, Eshak, Floriane, Malhaire, Fanny, Brabet, Isabelle, Prézeau, Laurent, Renard, Emma, Pin, Jean-Philippe, Acher, Francine, Staudt, Markus, Bunch, Lennart   +9 more
openaire   +4 more sources

The Marriage of Metal Nanoclusters With Reticular Frameworks: Synthetic Strategies and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of metal nanoclusters (MNCs) with reticular frameworks (RFs) has recently emerged as a powerful strategy to create composite materials with enhanced and synergistic functionalities. This review provides an overview of the synthetic strategies developed for constructing MNCs/RFs composites and their recent advances in biomedical ...
Wenfeng Liu, Qinyin Yin, Li‐Li Tan, Li Shang   +3 more
wiley   +1 more source

The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies [PDF]

, 2017
The goal of the AntiBotABE Program was the development of recombinant antibodies that neutralize botulinum neurotoxins (BoNT) A, B and E. These serotypes are lethal and responsible for most human botulinum cases.
Avril, Arnaud, Derman, Yagmur, Fontayne, Alexandre, Hust, Michael, Korkeala, Hannu, Mazuet, Christelle, Miethe, Sebastian, Pelat, Thibaut, Popoff, Michel R., Rasetti-Escargueil, Christine, Selby, Katja, Sesardic, Dorothea, Thullier, Philippe, Urbain, Remi   +13 more
core   +2 more sources

Fast-Track Discovery of SARS-CoV-2-Neutralizing Antibodies from Human B Cells by Direct Functional Screening

Viruses
As the COVID-19 pandemic revealed, rapid development of vaccines and therapeutic antibodies are crucial to guarantee a quick return to the status quo of society.
Matthias Hillenbrand, Christoph Esslinger, Jemima Seidenberg, Marcel Weber, Andreas Zingg, Catherine Townsend, Barbara Eicher, Justina Rutkauskaite, Peggy Riese, Carlos A. Guzman, Karsten Fischer, Simone Schmitt   +11 more
doaj   +1 more source