Results 101 to 110 of about 212,806 (232)

Antibody engineering for increased potency, breadth and half-life [PDF]

, 2015
Purpose of review: This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies.
Bjorkman, Pamela J., Scharf, Louise, Sievers, Stuart A., West, Anthony P., Jr.   +3 more
core   +1 more source

Next‐Generation Biosensors for Real‐Time Quality Monitoring in the Food Industry

Food Bioengineering, EarlyView.
This graphical abstract highlights the use of biosensors for real‐time monitoring of food quality and safety across grains, dairy, meat, seafood, fruits, beverages, bakery, and packaging. Central to this is signal processing, enabling rapid, accurate detection of contaminants, spoilage, and adulterants from farm to fork.
Drisya Raj M. P., Roopa Shri B., Chinta Suneetha, Kanimozhi N.V., Sonali L., Pavithra R., Ashok Kumar S., Palpandi Raja R., Sukumar M.   +8 more
wiley   +1 more source

Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells

Beilstein Journal of Organic Chemistry, 2019
Tubugi-1 is a small cytotoxic peptide with picomolar cytotoxicity. To improve its cancer cell targeting, it was conjugated using a universal, modular disulfide derivative.
Rainer Kufka, Robert Rennert, Goran N. Kaluđerović, Lutz Weber, Wolfgang Richter, Ludger A. Wessjohann   +5 more
doaj   +1 more source

A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells

Blood Advances, 2018
: The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression. Thus
Yelena Kovtun, Gregory E. Jones, Sharlene Adams, Lauren Harvey, Charlene A. Audette, Alan Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, Olga Ab, Yulius Setiady, Nicholas C. Yoder, Victor S. Goldmacher, Ravi V.J. Chari, Jan Pinkas, Thomas Chittenden   +16 more
doaj   +1 more source

2016 EMBO Chemical Biology Conference [PDF]

, 2017
From August 31st- September 3rd the biennual EMBO Chemical Biology conference, hosted by the European Molecular Biology Laboratory (EMBL) in Heidelberg took place.
Bantscheff, Beans, Beck, Beer, Bergamini, Blatter, Buntz, Carette, Chatterjee, Chouchani, Chowdhury, Conway, Dittmann, Du, Ferreras, Frank, Gaali, Hackl, Heinis, Holt, Höfer, Jia, Jones, Jung, Kapp, Kollmannsperger, Komor, Labòria, Lechner, Lun, Makley, Mapp, Melo Czekster, Minoshima, Nadler, Niinivehmas, Nikic, Pao, Pianowski, Plass, Prier, Renata, Schoffelen, Sellmyer, Winter, Yamagishi, Zheng   +46 more
core   +2 more sources

Grazer‐induced bioluminescence and toxicity in marine dinoflagellates

Limnology and Oceanography, EarlyView.
Abstract Marine copepods are the most abundant multicellular zooplankton in the global oceans. They imprint their surrounding waters with a unique bouquet of chemical compounds, including polar lipids such as copepodamides. Prey organisms can detect copepodamides and respond by inducing defensive traits including bioluminescence, toxin production ...
Paula Gonzalo‐Valmala, Milad Pourdanandeh, Sandra Lage, Erik Selander   +3 more
wiley   +1 more source

Reversible Sandwich‐Based Particle Nanoswitch for Continuous Protein Monitoring at Picomolar Concentrations with Automated Calibration

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
A reversible particle nanoswitch sensor enables continuous protein monitoring by forming transient sandwich complexes in the presence of analyte molecules. Site‐specific conjugations ensure optimal antibody fragment orientation. Demonstrated for lactoferrin, the sensor achieves picomolar sensitivity with ∼12 min time delay and continuous measurements ...
Claire M. S. Michielsen, Junhong Yan, Max H. Bergkamp, Yu‐Ting Lin, Stijn R. R. Haenen, Rafiq M. Lubken, Alexander Gräwe, Anna Swietlikowska, Arthur M. de Jong, Menno W. J. Prins   +9 more
wiley   +2 more sources

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Gadolinium Pollution—A Future Forward Perspective on Human and Environmental Impact

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT The widespread use of gadolinium‐based contrast agents (GBCAs) in magnetic resonance imaging (MRI) has been instrumental in enhancing diagnostic capabilities. However, the potential environmental and human health impacts of gadolinium pollution have become a growing concern.
Makayla R. Long, Nir A. Dayan, Meicai Xu, Wei Liao, Assaf A. Gilad, Mark C. DeLano   +5 more
wiley   +1 more source

Uptake of 3,3',5,5'-tetraiodothyroacetic acid and 3,3',5'-triiodothyronine in cultured rat anterior pituitary cells and their effects on thyrotropin secretion [PDF]

, 1995
We compared the uptake, metabolism, and biological effects of tetraiodothyroacetic acid (Tetrac) and rT3 in anterior pituitary cells with those of T4 and T3. Cells were isolated from adult male Wistar rats and cultured for 3
Docter, R. (Roel), Everts, M.E. (Maria), Hennemann, G. (George), Jong, M. (Marion) de, Krenning, E.P. (Eric), Moerings, E.P.C.M. (Ellis), Tempelaars, A.M., Toor, H. (Hans) van, Visser, T.J. (Theo)   +8 more
core   +1 more source