Results 111 to 120 of about 212,806 (232)

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source

Conformational Quenching in an Engineered Lipocalin Protein Achieves High Affinity Binding to the Toxin Colchicine

Angewandte Chemie, Volume 137, Issue 50, December 8, 2025.
Specific high affinity recognition of colchicine by an engineered anticalin involves loop dynamics and conformational selection Abstract The engineered lipocalin Colchicalin binds the clinically relevant plant toxin colchicine with picomolar affinity.
Mark J. Bostock, Christopher Kolloff, Elena Jerschke, Sam Asami, Arne Skerra, Simon Olsson, Michael Sattler   +6 more
wiley   +2 more sources

Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
Frontiers Production Office
doaj   +1 more source

Enhancing the miRNA Detection Sensitivity of DNA Origami Book Biosensors Using Lock Modifications and a Polymer Additive

Small, EarlyView.
A dynamic DNA origami book biosensor enables simultaneous detection of microRNA‐21 (miR‐21) and microRNA‐7a (miR‐7a) in plasma from breast cancer patients. Using fluorescence resonance energy transfer (FRET) and quenching readouts, this programmable nanostructure achieves enzyme‐free detection within 10 minutes, highlighting its potential for sensitive,
Ivana Domljanovic, Samet Kocabey, Guillermo P. Acuna, Curzio Ruegg   +3 more
wiley   +1 more source

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2023
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids [PDF]

, 2017
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Copple, Ian M., Dinkova-Kostova, Albena T., Goldring, Christopher E., Honda, Tadashi, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Park, B. Kevin, Shelton, Luke M., Walsh, Joanne   +9 more
core  

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens. [PDF]

, 2015
Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented by the major histocompatibility complex (pMHC) on the surface of professional antigen-presenting cells and infected or malignant cells. The efficiency of T
Alam, Aleksic, Aleksic, Alexander-Miller, Angelov, Artyomov, Atkins, Au-Yeung, Bachmann, Besser, Besser, Black, Boon, Borbulevych, Bos, Boulter, Brahmer, Brentville, Bridgeman, Bullock, Busch, Cameron, Campoli, Carreno, Carreno, Casas, Cebecauer, Chen, Chen, Chervin, Chlewicki, Cole, Corr, Corse, Corse, Coulie, Couzin-Frankel, Cukalac, Davis, Derby, Dolton, Dudley, Dudley, Dunn, Dushek, Dutoit, Dutoit, Dvorak, Dzutsev, Edwards, Engels, Engels, Faroudi, Fivash, Foley, Fonteneau, Fridman, Gallimore, Gannon, Garon, Gill, Gonzalez, Govern, Guillaume, Guy, Haidar, Hebeisen, Hebeisen, Hebeisen, Hodi, Holler, Holler, Holler, Hombrink, Hong, Huang, Huppa, Irving, Janicki, Jiang, Johnson, June, Kalergis, Keane, Kedl, Kersh, Klebanoff, Klein, Knabel, Krogsgaard, Kronig, Kunert, Kurts, Kyewski, La Gruta, Laugel, Li, Linette, Liu, Liu, Lovgren, Malecek, Malherbe, Matsui, McKeithan, McMahan, McMahan, Mellman, Morgan, Morgan, Nauerth, Nauerth, Neudorfer, Overwijk, Pages, Palmer, Palmer, Postow, Price, Pryshchep, Radvanyi, Restifo, Riquelme, Robbins, Robbins, Robbins, Robert, Robert, Romero, Rosenberg, Rosenberg, Rosenberg, Rosette, Salter, Savage, Schmid, Schmidt, Schmidt, Schmitt, Schumacher, Schwartzentruber, Slansky, Speiser, Speiser, Stone, Stone, Sykulev, Tan, Thomas, Tian, Topalian, Trautmann, Turner, Turula, Valitutti, Valitutti, Verdeil, Vigano, Vigano, Wang, Weiss, Wiedemann, Wilde, Wooldridge, Yee, Yee, Yeh, Zeh, Zehn, Zehn, Zehn, Zhao, Zhong, Zhu, Zhu, Zoete, Zoete   +176 more
core   +1 more source

Breaking the Low Concentration Barrier of Single‐Molecule Fluorescence Quantification to the Sub‐Picomolar Range

Small Methods, EarlyView.
Single‐molecule fluorescence detection can become highly challenging for diluted concentrations in the picomolar range. This “low concentration barrier” is broken into and achieves quantitative detection down to 0.1 pM. Introducing a diaphragm into a standard confocal microscope and implementing fluorescence lifetime correlation spectroscopy (FLCS ...
Malavika Kayyil Veedu, Jérôme Wenger
wiley   +1 more source

Selection and characterization of a broadly neutralizing class of HCV anti-E2 VH1-69 antibodies.

PLoS Pathogens
Identification and characterization of antibody epitope targets on the hepatitis C virus (HCV) envelope proteins remain crucial for developing an effective vaccine.
Andreas Soerensen, Filip Popovic, Christina Holmboe Olesen, Blanca Lopez Mendez, Brian Lohse, Zhaochun Chen, Patrizia Farci, Robert H Purcell, Harvey J Alter, Lea Klingenberg Barfod, Jens Bukh, Jannick Prentoe   +11 more
doaj   +1 more source

Characterization of a re‐engineered, mesothelin‐targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

Molecular Oncology, 2016
Mesothelin overexpression in lung adenocarcinomas correlates with the presence of activating KRAS mutations and poor prognosis. Hence SS1P, a mesothelin‐targeted immunotoxin, could offer valuable treatment options for these patients, but its use in solid
Frieder Bauss, Martin Lechmann, Ben-Fillippo Krippendorff, Roland Staack, Frank Herting, Matthias Festag, Sabine Imhof-Jung, Friederike Hesse, Marc Pompiati, Gwendlyn Kollmorgen, Rita da Silva Mateus Seidl, Birgit Bossenmaier, Wilma Lau, Christian Schantz, Jan O. Stracke, Ulrich Brinkmann, Masanori Onda, Ira Pastan, Klaus Bosslet, Gerhard Niederfellner   +19 more
doaj   +1 more source