Results 121 to 130 of about 212,806 (232)

Fungal DNA‐barcoding on a chip: Magnetoresistive biosensors for yeast infection diagnosis

VIEW, EarlyView.
The development of a fungal pathogen identification chip is herein demonstrated. Hybridization dynamics were tested against 58 species in silico and 4 species on chip. 95% accuracy, 91% sensitivity, 98% specificity and femtomolar limit of detection were achieved. Future perspectives include the integration of sample pre‐treatment modules.
Maria Zolotareva, Francisco Cascalheira, Rúben Afonso, Maria Corado, Ana Martins, Cátia Caneiras, Cristina Bárbara, Miguel Cacho Teixeira, Diogo Miguel Caetano   +8 more
wiley   +1 more source

Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]

, 2012
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O., Echeme, Johnbull O, Familoni, Oluwole B, Sujiang, Zheng, Wu, Feipeng   +4 more
core   +5 more sources

Phage Display Derived Antibodies Against Antimicrobial Peptide FsPDF2 Reveal Stress Response in European Beech

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant defensins (PDFs) are cysteine‐rich antimicrobial peptides (AMPs) that are important components of plant immunity. They occur constitutively in various plant tissues but are also upregulated upon stress. Therefore, these molecules are of great interest as markers for the diagnosis of early forest stress response in plants at the molecular
Philip Alexander Heine, Tetyana Nosenko, Sarah Kistner, Kevin Dennis Oliphant, Manuel Hanke‐Uhe, Afsheen Shahid, Bin Hu, Martin Kucklick, Nina Lehmler, Marlies Becker, Nicole Goerke, Janin Korn, Tanja Linke, Doris Meier, Asta Perl, Saskia Polten, Valeska Priess, Dorina Schäckermann, Maren Schubert, Jörg Schumacher, Jana Barbro Winkler, Susanne Engelmann, Heinz Rennenberg, Jörg‐Peter Schnitzler, Stefan Dübel, Michael Hust, Robert Hänsch, David Kaufholdt   +27 more
wiley   +1 more source

Fast-Track Discovery of SARS-CoV-2-Neutralizing Antibodies from Human B Cells by Direct Functional Screening

Viruses
As the COVID-19 pandemic revealed, rapid development of vaccines and therapeutic antibodies are crucial to guarantee a quick return to the status quo of society.
Matthias Hillenbrand, Christoph Esslinger, Jemima Seidenberg, Marcel Weber, Andreas Zingg, Catherine Townsend, Barbara Eicher, Justina Rutkauskaite, Peggy Riese, Carlos A. Guzman, Karsten Fischer, Simone Schmitt   +11 more
doaj   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach [PDF]

, 2016
The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective Neuropeptide Y Y4 receptor agonist. It represents a valuable candidate in developing traceable ligands for pharmacological studies of Y4 receptors, and as a lead ...
Briddon S., Gehlert D. R., Marleen Groenen, Mengjie Liu, Michel M. C., Nicholas D. Holliday, Philip E. Thompson, Rachel R. Richardson, Schober D. A., Simon J. Mountford, Uhe A. M.   +10 more
core   +2 more sources

Duckweeds: Model organisms for research on plant sterols and steroids

Plant Biology, Volume 28, Issue 1, Page 18-30, January 2026.
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
J. Klein, K.‐J. Appenroth, K. S. Sree
wiley   +1 more source

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease [PDF]

, 2018
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5.
Bauer, CC, Beech, DJ, Bon, RS, Minard, A, Muraki, K, Rubaiy, HN, Wright, DJ   +6 more
core   +2 more sources

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library [PDF]

, 2018
The diverse physiological roles of the neurotrophin family have long prompted exploration of their potential as therapeutic agents for nerve injury and neurodegenerative diseases.
Allen, Nicholas D., Barde, Yves-Alain, Binley, Kate E., Chacon-Fernandez, Pedro, DiStefano, Peter S., Grande, Geramie, Lerner, Richard A., Li, Meng, Lin, Chih-Wei, Lindsay, Ronald M., Merkouris, Spyros, Nan, Xinsheng, Stepanov, Alexey V., Wu, Nicholas C., Xie, Jia   +14 more
core   +2 more sources

Structure-guided development of heterodimer-selective GPCR ligands [PDF]

, 2016
Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for ...
Clark, Tim, Gienger, Marie, Gmeiner, Peter, Hübner, Harald, Kaindl, Jonas, Leeb, Laurin, Möller, Dorothee, Schaab, Carolin, Schellhorn, Tamara   +8 more
core   +1 more source