Results 131 to 140 of about 212,806 (232)

Introducing Quantitative Assessment of Michaelis Constant (Km) Accuracy

ChemBioChem, Volume 26, Issue 24, December 11, 2025.
The Michaelis constant (Km) is often reported with misleading confidence when only standard errors are considered. The accuracy confidence interval (ACI) framework is adapted to Km by recasting velocity–substrate data as a binding isotherm, propagating systematic uncertainties in enzyme and substrate concentrations.
Tong Ye Wang, Parmeetpal Dhillon, Svetlana M. Krylova, Amit Bijlani, Sebastian Schreiber, Dasantila Golemi‐Kotra, Joachim Jose, Sergey N. Krylov   +7 more
wiley   +1 more source

Should NS5A inhibitors serve as the scaffold for all-oral anti-HCV combination therapies?

Hepatic Medicine: Evidence and Research, 2015
Sujit V Janardhan, Nancy S Reau Center for Liver Diseases, Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA Abstract: Chronic hepatitis C virus (HCV) infection represents a global ...
Janardhan SV, Reau NS
doaj  

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.

PLoS Pathogens
Lenacapavir (LEN) is a highly potent, long-acting antiretroviral medication for treating people infected with muti-drug-resistant HIV-1 phenotypes. The inhibitor targets multifaceted functions of the viral capsid protein (CA) during HIV-1 replication ...
Szu-Wei Huang, Lorenzo Briganti, Arun S Annamalai, Juliet Greenwood, Nikoloz Shkriabai, Reed Haney, Michael L Armstrong, Michael F Wempe, Satya Prakash Singh, Ashwanth C Francis, Alan N Engelman, Mamuka Kvaratskhelia   +11 more
doaj   +1 more source

Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus

Journal of Biological Chemistry, 2018
Enfuvirtide (T20) is the only viral fusion inhibitor approved for clinical use, but it has relatively weak anti-HIV activity and easily induces drug resistance.
Yuanmei Zhu, Xiujuan Zhang, Xiaohui Ding, Huihui Chong, S. Cui, Jinsheng He, Xinquan Wang, Yuxian He   +7 more
semanticscholar   +1 more source

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, Volume 37, Issue 49, December 10, 2025.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

The Role of Porosity in SERS

Advanced Optical Materials, Volume 13, Issue 34, December 2, 2025.
This review explores how engineered porous materials enhance surface‐enhanced Raman scatering (SERS) spectroscopy by synergizing analyte enrichment and electromagnetic field amplification. It is systematically evaluated four classes, nanoporous metals, plasmonic polymers, mesoporous silica, and metal‐organic frameworks (MOFs), highlighting their unique
Miguel A. Correa‐Duarte, I. Brian Becerril‐Castro, Ramon A. Alvarez‐Puebla   +2 more
wiley   +1 more source

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, Volume 4, Issue 12, December 2025.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

MXene‐Based Electrochemiluminescence (ECL) Biosensors: A Review on Analyte Detection and Diagnostic Applications

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
This review highlights recent advances in MXene‐based electrochemiluminescence (ECL) biosensors, showcasing their exceptional sensitivity and versatility in detecting biomolecules, pathogens, and environmental pollutants. The integration of MXenes significantly enhances ECL signal amplification, paving the way for next‐generation diagnostic and ...
Kai Zhang
wiley   +1 more source