Results 131 to 140 of about 9,317 (205)

Observing Picomolar Protein Unfolding Using Resonance Light Scattering. [PDF]

Biomolecules
Bolaño Alvarez A, Arvesen KB, Hjuler KF, Bjerring P, Petersen SB.   +4 more
europepmc   +1 more source

Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation. [PDF]

MAbs
Grace J, Colin PY, Foxler D, Haynes W, Howsham C, Kassimatis L, Mavrogonatou L, Mighell R, McClory J, Mullin M, Ogola T, Townsend A, Ravi S, Wossnig L, van Heeke G.   +14 more
europepmc   +1 more source

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis. [PDF]

J Med Chem
Canales E, Tse W, Schroeder SD, Chou CH, Liu Q, Zhang J, Lazerwith SE, Morganelli P, Saito RD, Brizgys G, Li J, Wu Q, Graupe M, Halcomb RL, Desai M, Cannizzaro C, Hu E, Perry JK, Villaseñor AG, Somoza JR, Ferrao RD, Swaminathan S, Zheng J, Lu B, Mwangi J, Wang K, Subramanian R, Smith BJ, Rhodes G, Rowe W, Sauer D, Lad L, Papalia GA, Clancy S, Stepan GJ, Yu H, Sakowicz R, Shi B, Carr G, Bam RA, Tsai LK, Singer E, Hansen D, Mulato A, Yant SR, Cihlar T, Link JO.   +46 more
europepmc   +1 more source

Disrupting the SHOC2-RAS Nexus: a new frontier in targeting RAS-Driven cancers. [PDF]

Mol Biomed
Huang Y, Chen Z, Qu S.
europepmc   +1 more source

Novel Flavonoid Derivatives Show Potent Efficacy in Human Lymphoma Models. [PDF]

EJHaem
Gaudio E, Biniecka P, Arribas AJ, Cannas E, Zaman GJR, Unutmaz D, Bertoni F, Stoicescu DF.   +7 more
europepmc   +1 more source

Dual-targeting strategy enables extremely potent and broad inhibition of emerging MERS-related coronaviruses. [PDF]

Cell Discov
Jiao F, Jin S, Wang Q, Xu W, Wang X, Sun F, Lu L, Jiang S, Zhu Y, Xia S.   +9 more
europepmc   +1 more source

Recent advances in bispecific antibody-drug conjugates for breast cancer therapy. [PDF]

Cancer Chemother Pharmacol
Ji X, Yang Y, Ma C, Huang W, Guo S, Wang L, Zheng H, Wu X.   +7 more
europepmc   +1 more source

Total Synthesis of (+)-Disorazole Z1. [PDF]

Chemistry
Bauer TJ, Aminian S, Spieß O, Schinzer D.   +3 more
europepmc   +1 more source

Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity. [PDF]

Acta Pharm Sin B
Che T, Chen Y, Cheng X, Hu H, Wu X, Zhang Y, Yang X, Liu Y, Liu H, Nan W, Wan S, Yang M, Zeng B, Li J, Zhang J, Xiong B.   +15 more
europepmc   +1 more source

Engineering a Coiled-Coil Protein for DARPin Presentation as a Potent SARS-CoV-2 Therapeutic. [PDF]

Biomacromolecules
Mai LD, Cheedarla N, Krishnathas S, Sadab IH, Gray MA, Lv W, Dhankher A, Roback JD, Neish AS, Champion JA.   +9 more
europepmc   +1 more source