Results 141 to 150 of about 212,806 (232)

An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity

Pharmaceutics
The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type 2 (SARS-CoV-2 or COVID-
DongHoon Yu, Sabrina Wagner, Martin Schütz, Yeejin Jeon, Mooyoung Seo, Jaeseung Kim, Nadine Brückner, Jintawee Kicuntod, Julia Tillmanns, Christina Wangen, Friedrich Hahn, Benedikt B. Kaufer, Frank Neipel, Jan Eickhoff, Bert Klebl, Kiyean Nam, Manfred Marschall   +16 more
doaj   +1 more source

Responses to Ligand Binding in the Bacterial DNA Sliding Clamp “β‐Clamp” Manifest in Dynamic Allosteric Effects

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 12, Page 2193-2210, December 2025.
ABSTRACT The homo‐dimeric, ring‐shaped bacterial DNA sliding clamp, β‐clamp, is a central hub in DNA replication and repair. It interacts with a plethora of proteins via their short linear motifs, binding to the same hydrophobic binding pocket on β‐clamp. Although the structure, functions, and interactions of β‐clamp have been amply studied, less focus
Signe Simonsen, Andreas Prestel, Eva C. Østerlund, Marit Otterlei, Thomas J. D. Jørgensen, Birthe B. Kragelund   +5 more
wiley   +1 more source

Topically Applied Recombinant Chemokine Analogues Fully Protect Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge [PDF]

, 2017
Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models.
Green, Linda C., Hartley, Oliver, Lederman, Michael M., Lifson, Jeffrey D., Ling, Binhua, Mosier, Donald, Offord, Robin, Piatak, Michael, Ribka, Erin P., Veazey, Ronald S.   +9 more
core  

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, Volume 116, Issue 12, Page 3250-3265, December 2025.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Shared mechanistic pathways of glucagon signalling: Unlocking its potential for treating obesity, metabolic dysfunction‐associated steatotic liver disease, and other cardio‐kidney‐metabolic conditions

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6869-6883, December 2025.
Abstract Glucagon is a pancreatic peptide hormone whose receptor (GCGR) is expressed in the liver, kidney, and, to a lesser extent, various other tissues. Glucagon is well known as the counterpart to insulin in glucose homeostasis. However, recent evidence has revealed other potential roles of glucagon, which include the regulation of amino acid ...
Guy W. Neff
wiley   +1 more source

Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection

JHEP Reports
Background & Aims: Chronic hepatitis delta virus (HDV) infection represents the most severe form of viral hepatitis. HDV is a satellite virus of hepatitis B virus (HBV) and depends on the hepatitis B surface antigen (HBsAg) for envelopment and viral ...
Jiayi Zhou, Hannah Kaiser, Evelyn Rocha, Ashley N. Terrell, Davide Corti, Lisa A. Purcell, Florian A. Lempp, Andreas S. Puschnik   +7 more
doaj   +1 more source

Proposition of Hyper‐Chemical Exchange Saturation Transfer Subtraction Spectroscopy to Detect Very Weak and Broad Signals Hidden Under Baseline and Widen Range of Materials Accessed by Hyperpolarized 129Xe NMR

ChemPhysChem, Volume 26, Issue 23, November 28, 2025.
A polyimide sample, for which hyperpolarized 129Xe NMR spectroscopy failed to detect 129Xe embedded in the polymer (Inset A), is found to give a very broad peak, line width 11 kHz at 206.5 ppm, by applying the stopped‐flow hyper‐chemical exchange saturation transfer subtraction spectroscopy on the continuous‐flow recirculating hyper‐polarization system
Hideaki Fujiwara, Hirohiko Imai, Atsuomi Kimura   +2 more
wiley   +1 more source

Approaches to hepatitis C treatment and cure using NS5A inhibitors

Infection and Drug Resistance, 2014
James J Kohler,1,2 James H Nettles,1,2 Franck Amblard,1,2 Selwyn J Hurwitz,1,2 Leda Bassit,1,2 Richard A Stanton,1 Maryam Ehteshami,1 Raymond F Schinazi1,2 1Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine ...
Kohler JJ, Nettles JH, Amblard F, Hurwitz SJ, Bassit L, Stanton RA, Ehteshami M, Schinazi RF   +7 more
doaj  

Combinatorial Chemistry Online Volume 15, Issue 5, May 2013 [PDF]

, 1963
Terrett, N.K.
core   +8 more sources

A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases. [PDF]

J Biol Chem
Rivera P, Lu S, Ngango D, Sankaran B, Venkataram Prasad B, Palzkill T.   +5 more
europepmc   +1 more source