Results 171 to 180 of about 213,179 (224)

Deferasirox Derivatives as Inhibitors of Kallikrein-Related Peptidases Associated to Neurodegenerative Diseases. [PDF]

ChemMedChem
Boumali R, David E, Chaaya N, Lucas M, Aït Amiri S, Lefort V, Nina-Diogo A, Salmain M, Petropoulos I, Corcé V, El Amri C, Botuha C.   +11 more
europepmc   +1 more source

Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499. [PDF]

Antimicrob Agents Chemother
Wang C, Huang H, Valera L, Parcella K, Iwuagwu C, McAuliffe B, Falk PJ, O'Boyle Ii DR, Rose RE, Padilla RR, Wu C, Xiong Y, Kadow J, Hanumegowda U, Sardo L, Gillis EP, Krystal M, Fridell RA.   +17 more
europepmc   +1 more source

Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion <i>Centruroides villegasi</i>. [PDF]

Toxins (Basel)
Shakeel K, Naseem MU, Olamendi-Portugal T, Zamudio FZ, Possani LD, Panyi G.   +5 more
europepmc   +1 more source

KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors. [PDF]

Mol Cancer Ther
Chutake YK, Mayo MF, Dumont N, Filiatrault J, Breitkopf SB, Cho P, Chen D, Dixit VS, Proctor WR, Kuhn EW, Bollinger Martinez S, McDonald AA, Qi J, Hu KN, Karnik R, Growney JD, Sharma K, Schalm SS, Gollerkeri AM, Mainolfi N, Williams JA, Weiss MM.   +21 more
europepmc   +1 more source

Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants

ChemMedChem, 2018
Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Satish Kovela, M. Brindisi, Heather L. Osswald, Bhavanam Sekhara Reddy, J. Agniswamy, Yuan‐Fang Wang, M. Aoki, S. Hattori, I. Weber, H. Mitsuya   +12 more
semanticscholar   +1 more source

Expanding the repertoire of Antibody Drug Conjugate (ADC) targets with improved tumor selectivity and range of potent payloads through in-silico analysis. [PDF]

PLoS One
Kathad U, Biyani N, Peru Y Colón De Portugal RL, Zhou J, Kochat H, Bhatia K.   +5 more
europepmc   +1 more source

How a Medicinal Chemistry Project Changed the Way Prostate Cancer is Diagnosed and Treated. [PDF]

J Med Chem
Kozikowski AP, Neale J.
europepmc   +1 more source

Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders. [PDF]

J Transl Autoimmun
Shakya A, Liu Q, Lai C, Baker S, Greene S, Erdman P, Rathnayake A, Schoolmeesters A, Blair CM, Kyurkchieva E, Rajapakse N, Lam I, Sin YY, Baillie GS, Huang S, Chourasia AH, Fung L.   +16 more
europepmc   +1 more source

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV ‑ 1 Protease in Conferring Drug Resistance

, 2019
M. Henes, G. J. Lockbaum, K. Kosovrasti, F. Leidner, G. Nachum, E. Nalivaika, Sook-Kyung Lee, E. Spielvogel, S. Zhou, R. Swanstrom, Daniel N. A. Bolon, N. K. Yilmaz, Celia A. Schi, Er   +13 more
semanticscholar   +1 more source

Drugging Challenging Cancer Targets Using Fragment-Based Methods. [PDF]

Chem Rev
Fesik SW.
europepmc   +1 more source