Results 181 to 190 of about 213,179 (224)

Hepatocellular Carcinoma and Antibody Drug Conjugates: A Systematic Review. [PDF]

Cureus
Maddukuri S, Haddad RR, Battula NS, Chay T, Patel T, Dumaru N, Mohammed L.   +6 more
europepmc   +1 more source

A human monoclonal antibody based immunoenzymetric assay to measure Fel d 1 concentrations in cat hair and pelt allergenic extracts. [PDF]

Front Allergy
Rabin RL, Croote D, Chen A, Dobrovolskaia E, Wong JJW, Grossman J, Hamilton RG.   +6 more
europepmc   +1 more source

An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors. [PDF]

J Med Chem
Fabbrizi E, Chernyshov VV, Fiorentino F, Sbardella G, Ragno R, Nawrozkij M, Ivanov R, Rotili D, Mai A.   +8 more
europepmc   +1 more source

Recent progress in therapeutic applications of fluorinated five-membered heterocycles and their benzo-fused systems. [PDF]

RSC Adv
Abbas AA, Farghaly TA, Dawood KM.
europepmc   +1 more source

Evolution of structure-guided drug design strategies targeting mutations in codon 12 of KRAS. [PDF]

RSC Med Chem
Dorandish S, Bhayekar K, Singh A, Kushwaha ND, Malin E, Serafimovski S, Kelm JM, Gavande NS, Lakkaniga NR.   +8 more
europepmc   +1 more source

T-Cell Engagers in Acute Myeloid Leukemia: Molecular Targets, Structure, and Therapeutic Challenges. [PDF]

Cancers (Basel)
Daws H, Gallinero K, Singh A, Bilic S.
europepmc   +1 more source

Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies. [PDF]

Proc Natl Acad Sci U S A
Mazigi O, Langley DB, Henry JY, Burnett DL, Sobti M, Walker GJ, Rouet R, Balachandran H, Lenthall H, Jackson J, Ubiparipovic S, Schofield P, Brown SHJ, Schulz SR, Hoffmann M, Pöhlmann S, Post J, Martinello M, Ahlenstiel G, Kelleher A, Rawlinson WD, Turville SG, Bull RA, Stewart AG, Jäck HM, Goodnow CC, Christ D.   +26 more
europepmc   +1 more source

Discovery of electrophilic degraders that exploit SNAr chemistry

Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Slabicki M, Fischer ES, Ebert BL, Gray NS.   +13 more
europepmc   +1 more source

NF449, a novel picomolar potency antagonist at human P2X1 receptors

European Journal of Pharmacology, 2003
The antagonistic effects of the novel suramin analogue 4,4',4",4"'-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid (NF449) were analyzed at homomeric human P2X(1) and P2X(7) receptor subtypes (hP2X(1) and hP2X(7)) heterologously expressed in Xenopus oocytes using the two-microelectrode voltage-clamp ...
Martin Hülsmann, Peter Nickel, Matthias U. Kassack, Günther Schmalzing, Günter Lambrecht, F Markwárdt   +5 more
semanticscholar   +5 more sources

Inhibition of gastric acid secretion by human calcitonin gene-related peptide with picomolar potency in guinea-pig parietal cell preparations

Biochemical and Biophysical Research Communications, 1987
The effect of CGRP on [14C]-aminopyrine accumulation in isolated parietal cell preparations from guinea-pig fundic mucosa was studied. Parietal cells consisted of 60% of the preparations. [14C]-Aminopyrine accumulation was used as an index of physiological response of parietal cells to secretagogues.
Yukio Umeda, Toshikazu Okada
semanticscholar   +4 more sources