Results 201 to 210 of about 213,179 (224)

Predicting the Impact of Drug Resistance Mutations on Inhibitor Potency with Molecular Dynamics and Machine Learning.

Journal of Physical Chemistry B
Many enzymes are vital drug targets in diseases such as cancer and pathogenic infections; however, mutations can drastically disrupt inhibitor binding to confer resistance.
Lauren E Intravaia, Ala M. Shaqra, Somayeh Pirhadi, Noa Popko, Nese Kurt Yilmaz, Celia A. Schiffer   +5 more
semanticscholar   +1 more source

Abstract 334: proPBD-ADCs: optimization of therapeutic potential of ADCs based on capped PBD payload with attenuated potency

Cancer Research
Antibody-drug conjugates (ADCs) with pyrrolobenzodiazepine (PBD) dimer payloads have been explored preclinically and several PBD-based ADCs entered clinical trials.
Anette Sommer, R. van Geel, Sander van Berkel, Elias Post, Jorin Hoogenboom, Floris van Delft   +5 more
semanticscholar   +1 more source

Alkoxy chain length governs the potency of 2-benzylbenzimidazole ‘nitazene’ opioids associated with human overdose

Psychopharmacology, 2023
G. Glatfelter, Marthe M. Vandeputte, Li Chen, Donna Walther, Meng-Hua M. Tsai, Lei Shi, Christophe P. Stove, Michael H. Baumann   +7 more
semanticscholar   +1 more source

Toxic potency-adjusted control of air pollution for solid fuel combustion

Nature Energy, 2022
Haotian Zheng, Qing Li, Ling Jin
exaly  

Designing spatial and temporal control of vaccine responses

Nature Reviews Materials, 2021
Shih Hao Ou, Wei Luo, Bali Pulendran
exaly  

Tailoring Aggregation Extent of Photosensitizers to Boost Phototherapy Potency for Eliciting Systemic Antitumor Immunity

Advanced Materials, 2022
Hao Zhao, Jiabao Xu, Lin Bao
exaly  

Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency

Advanced Materials, 2023
Pieter Cullis
exaly  

Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Nature Reviews Microbiology, 2020
Jessa Marie V Makabenta, Ahmed Nabawy, Cheng-Hsuan Li   +2 more
exaly  

High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models

Cell, 2020
Wei Li, Alexandra Schäfer, Swarali S Kulkarni   +2 more
exaly  

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Nature Medicine, 2018
Jie Sun, Justin Eyquem, Yu-jui Ho
exaly