Results 41 to 50 of about 9,317 (205)

Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity [version 1; referees: 2 approved]

F1000Research, 2018
In humans and other mammals, recognition of endotoxins—abundant surface lipopolysaccharides (LPS) of Gram-negative bacteria—provides a potent stimulus for induction of inflammation and mobilization of host defenses. The structurally unique lipid A region
Jerrold Weiss, Jason Barker
doaj   +1 more source

A Cell Line for Detection of Botulinum Neurotoxin Type B [PDF]

, 2017
Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.
Adler, Antonucci, Arsenault, Bak, Binz, Binz, Boute, Chaddock, Davletov, Erbguth, Fernández-Salas, Ferreira, Foran, Foran, Foster, Gordon, Koriazova, Lacy, Lacy, Marini, Montecucco, Montecucco, Pirazzini, Puhar, Rossetto, Rummel, Rust, Schiavo, Sesardic, Strotmeier, Swift, Whitemarsh, Wictome, Wild, Yowler, Yu   +35 more
core   +2 more sources

Trypanosoma brucei DHRF-TS revisited:characterisation of a bifunctional and highly unstable recombinant dihydrofolate reductase-thymidylate synthase [PDF]

, 2016
Bifunctional dihydrofolate reductase–thymidylate synthase (DHFR-TS) is a chemically and genetically validated target in African trypanosomes, causative agents of sleeping sickness in humans and nagana in cattle.
A Dawson, A El Fadili, A Khodursky, AJ Wahba, AJ Wahba, AL Jackman, Alan H. Fairlamb, B Nare, BJ Dolnick, C Fraser-Lhostis, C Shih, CJ Allegra, CW Carreras, D Spinks, DC Jones, E Wirtz, EJ Shanks, EL White, F Gamarro, FW Studier, H Zhang, Han B. Ong, HB Ong, J Phan, J Yuvaniyama, JA Frearson, Jayne Raper, JF Morrison, JM Blaney, JR Appleman, K Al Chalabi, KY Han, LM Changchien, LS Torrie, M Berriman, M Hekmat-Nejad, Marc W. Gibson, MM Bradford, N Greig, N Sienkiewicz, N Sienkiewicz, Natasha Sienkiewicz, ND Brunn, P Prapunwattana, P Reche, PH Liang, R Ferone, R Grumont, RA Copeland, RC Jackson, RD Walter, RJ Bonney, RJ Cisneros, S Shallom, SA Margosiak, SE Webber, SF Chowdhury, SI Ahmad, Simon Dewar, SM Lanham, TC Eadsforth, TD Meek, TW Synold, Y Cheng   +63 more
core   +3 more sources

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources

A potent human neutralizing antibody Fc-dependently reduces established HBV infections

eLife, 2017
Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its ...
Dan Li, Wenhui He, Ximing Liu, Sanduo Zheng, Yonghe Qi, Huiyu Li, Fengfeng Mao, Juan Liu, Yinyan Sun, Lijing Pan, Kaixin Du, Keqiong Ye, Wenhui Li, Jianhua Sui   +13 more
doaj   +1 more source

Highlights from the 24th conference on retroviruses and opportunistic infections, 13-16 February 2017, Seattle, Washington, USA [PDF]

, 2017
From the 13th to 16th February 2017, researchers from around the world convened for the 24th annual Conference on Retroviruses and Opportunistic Infections (CROI) at the Washington State Convention Center in Seattle, Washington.
Bhagani, Sanjay, Colby, Donn J, Crowell, Trevor A, Gathogo, Esther N, Hill, Andrew, Hsu, Denise, Kinloch, Sabine, Lyall, Hermione, Malatinková, Eva, Polyak, Christina, Psomas, Christina, Trypsteen, Wim, Vandekerckhove, Linos   +12 more
core   +5 more sources

Synthesis, In Silico and In Vitro Characterization of Novel N,N-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

Pharmaceuticals, 2023
The translocator protein (TSPO) is an interesting biological target for molecular imaging and therapy because the overexpression of TSPO is associated with microglial activation caused by neuronal damage or neuroinflammation, and these activated ...
Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam, Sang-Yoon Lee   +6 more
doaj   +1 more source

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV [PDF]

, 2015
Protein microbicides containing neutralizing antibodies and antiviral lectins may help to reduce the rate of infection with human immunodeficiency virus (HIV) if it is possible to manufacture the components in large quantities at a cost affordable in HIV‐
Arcalis, E, Capell, T, Christou, P, Evans, A, Medina, V, O'Keefe, BR, Ramessar, K, Shattock, RJ, Stöger, E, Vamvaka, E   +9 more
core   +2 more sources

cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]

, 2015
A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
core   +2 more sources

Nanophotonic Strategies for Chiral Biosensing: Nanoparticles, Metasurfaces, Magneto‐Optical, and Quantum Approaches

Advanced Photonics Research, EarlyView.
Recent advances in nanophotonics‐based chiral biosensing approaches are comprehensively reviewed, highlighting key trends, advantages, and limitations of each technology. Special attention is given to emerging strategies that exploit magneto‐optical and quantum plasmonic phenomena to enhance sensitivity down to the level of a few molecules, or even a ...
Jorge Ricardo Mejía‐Salazar
wiley   +1 more source