Results 51 to 60 of about 212,806 (232)

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy [PDF]

, 2012
Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by ...
Burkhart, Jens L., Eirich, Jürgen, Kazmaier, Uli, Rudolf, Georg C., Sieber, Stephan A., Ullrich, Angelika, Vollmar, Angelika M., Zahler, Stefan   +7 more
core   +1 more source

S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases

Journal of Translational Autoimmunity, 2021
Increased interferon-α (IFN-α) production is a critical component in the pathophysiology of systemic lupus erythematosus (SLE) and other rheumatic autoimmune diseases.
Fanny Duguet, Céline Ortega-Ferreira, Benjamin Fould, Hélène Darville, Sylvie Berger, Agnès Chomel, Grégory Leclerc, Kai Kisand, Liis Haljasmägi, Adrian C. Hayday, Emiko Desvaux, Emmanuel Nony, Philippe Moingeon, Frédéric De Ceuninck   +13 more
doaj   +1 more source

Optimization of a class of tryptophan dendrimers that inhibit HIV replication leads to a selective, specific, and low-nanomolar inhibitor of clinical isolates of enterovirus A71 [PDF]

, 2016
Tryptophan dendrimers that inhibit HIV replication by binding to the HIV envelope glycoproteins gp120 and gp41 have unexpectedly also proven to be potent, specific, and selective inhibitors of the replication of the unrelated enterovirus A71.
Camarasa Rius, María José, Delang, Leen, Donckers, K., García Doyagüez, Elisa, Leyssen, Pieter, Martínez-Gualda, B., Neyts, Johan, Quesada, Ernesto, Rivero-Buceta, Eva, San-Félix, Ana, Sun, L.   +10 more
core   +1 more source

Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications.

Journal of the American Chemical Society, 2022
Owing to its roles in human health and disease, the modification of nuclear, cytoplasmic, and mitochondrial proteins with O-linked N-acetylglucosamine residues (O-GlcNAc) has emerged as a topic of great interest.
M. González-Cuesta, Peter Sidhu, Roger A. Ashmus, A. Males, Cameron Proceviat, Zarina Madden, J. Rogalski, Jil A. Busmann, L. Foster, J. G. García Fernández, G. Davies, C. Ortiz Mellet, D. Vocadlo   +12 more
semanticscholar   +1 more source

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

Neurobiology of Disease, 2021
A growing body of evidence suggests that aggregated α-synuclein, the major constituent of Lewy bodies, plays a key role in the pathogenesis of Parkinson's disease and related α-synucleinopathies.
Eva Nordström, Fredrik Eriksson, Jessica Sigvardson, Malin Johannesson, Alex Kasrayan, Martina Jones-Kostalla, Paulina Appelkvist, Linda Söderberg, Patrik Nygren, Magdalena Blom, Adeline Rachalski, Karin Nordenankar, Olof Zachrisson, Ebba Amandius, Gunilla Osswald, Mikael Moge, Martin Ingelsson, Joakim Bergström, Lars Lannfelt, Christer Möller, Marco Giorgetti, Johanna Fälting   +21 more
doaj   +1 more source

A Cell Line for Detection of Botulinum Neurotoxin Type B [PDF]

, 2017
Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.
Adler, Antonucci, Arsenault, Bak, Binz, Binz, Boute, Chaddock, Davletov, Erbguth, Fernández-Salas, Ferreira, Foran, Foran, Foster, Gordon, Koriazova, Lacy, Lacy, Marini, Montecucco, Montecucco, Pirazzini, Puhar, Rossetto, Rummel, Rust, Schiavo, Sesardic, Strotmeier, Swift, Whitemarsh, Wictome, Wild, Yowler, Yu   +35 more
core   +2 more sources

A time-resolved fluorescence immunoassay for the measurement of testosterone in saliva: Monitoring of testosterone replacement therapy with testosterone buciclate [PDF]

, 1998
Monitoring of testosterone replacement therapy requires a reliable method for testosterone measurement. Determination of salivary testosterone, which reflects the hormone's biologically active plasma fraction, is a superior technique for this purpose ...
Bals-Pratsch M, Blight LF, Dabbs, Ferguson DB, Meulenberg EP, Osredkar J, Pardridge WM, Schramm W, Schürmeyer T, Smith RG, Soini E, Strasburger CJ, Swinkels LM, Swinkels LM   +13 more
core   +1 more source

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants

mAbs, 2022
Coronavirus disease 2019, caused by SARS-CoV-2, remains an on-going pandemic, partly due to the emergence of variant viruses that can “break-through” the protection of the current vaccines and neutralizing antibodies (nAbs), highlighting the needs for ...
Bo-Seong Jeong, J. S. Cha, Insu Hwang, U. Kim, Jared Adolf-Bryfogle, B. Coventry, H. Cho, Kyun-Do Kim, B. Oh   +8 more
semanticscholar   +1 more source

De Novo Design of High‐Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

Angewandte Chemie, EarlyView.
Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic, Buwei Huang, Andi Liu, Lieselotte S.M. Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K. Bera, Alex Kang, Stacey R. Gerben, Stephen Rettie, Dionne K. Vafeados, Nicole Roullier, Inna Goreshnik, Xinting Li, David Baker, Joshua J. Woodward, Joseph D. Mougous, Gaurav Bhardwaj   +18 more
wiley   +2 more sources

Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity [version 1; referees: 2 approved]

F1000Research, 2018
In humans and other mammals, recognition of endotoxins—abundant surface lipopolysaccharides (LPS) of Gram-negative bacteria—provides a potent stimulus for induction of inflammation and mobilization of host defenses. The structurally unique lipid A region
Jerrold Weiss, Jason Barker
doaj   +1 more source