Results 171 to 180 of about 26,015 (214)

Divergent picornavirus IRES elements

open access: yesVirus Research, 2009
Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA.
Graham J Belsham
exaly   +5 more sources

Picornavirus inhibitors

open access: yesPharmacology & Therapeutics, 1994
Picornaviruses are among the best understood animal viruses in molecular terms. A number of important human and animal pathogens are members of the Picornaviridae family. The genome organization, the different steps of picornavirus growth and numerous compounds that have been reported as inhibitors of picornavirus functions are reviewed.
Luis Carrasco
exaly   +3 more sources
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Intracellular determinants of picornavirus replication

Trends in Microbiology, 1999
Viruses replicate in a restricted number of hosts and tissues. In addition to viral receptors, several intracellular factors can be involved in determining tissue tropism. Many proteins have recently been implicated in picornavirus translation and RNA replication.
Raúl Andino, Andrea V Gamarnik
exaly   +3 more sources

Picornavirus Entry

2013
The essential event in picornavirus entry is the delivery of the RNA genome to the cytoplasm of a target cell, where replication occurs. In the past several years progress has been made in understanding the structural changes in the virion important for uncoating and RNA release. In addition, for several viruses the endocytic mechanisms responsible for
Jeffrey M, Bergelson, Carolyn B, Coyne
openaire   +2 more sources

Picornavirus–receptor interactions

Trends in Microbiology, 2002
Many picornaviruses use cell-surface molecules belonging to the immunoglobulin superfamily (IgSF) as their cellular receptors. These molecules usually consist of tandem repeats of between two and five Ig-like domains whose amino-terminal domains (D1) interact with invading viruses, with their carboxy-terminal sections comprising a transmembrane and a ...
Michael G, Rossmann   +2 more
openaire   +2 more sources

Treatment of picornavirus infections

Antiviral Research, 2002
The picornaviruses are a diverse group of viral pathogens that together comprise the most common causes of infections of humans in the developed world. Within the picornavirus family are three well-known groups of human pathogens-the enteroviruses (including polioviruses, coxsackieviruses, and echoviruses), the rhinoviruses, and the hepatoviruses ...
exaly   +3 more sources

Enterovirus/Picornavirus infections

2014
Abstract The human enteroviruses (EV) comprise one group of the picornavirus family. The best known members are the polioviruses (PV), coxsackieviruses, and echoviruses. They replicate in the oropharynx and gastrointestinal (GI) tract and are primarily spread by fecal-hand-oral contamination.
Burk, Jubelt, Howard L, Lipton
openaire   +2 more sources

PICORNAVIRUS EPIDEMIC CONJUNCTIVITIS IN SINGAPORE

Lancet, The, 1972
Abstract Outbreaks of picornavirus epidemic conjunctivitis in 1970 and 1971 in Singapore have been studied. The 1971 outbreak was caused by a virus identical or closely related to the acute haemorrhagic conjunctivitis (A.H.C.) virus isolated in Japan in 1971, and not by reappearance of the Singapore epidemic conjunctivitis (S.E.C.) virus (1970). The S.
M Yin-Murphy
exaly   +3 more sources

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