Results 61 to 70 of about 21,155 (219)

Preventive effect of Moringa oleifera seed oil (MOSEIL) in mice (Mus musculus) liver fibrosis model [PDF]

BIO Web of Conferences
Persistent liver injury leads to liver fibrosis, a pathological condition distinguished by the excessive deposition of extracellular matrix components, especially collagen.
Azizah Khulud Rizqi, Susanto Hendra, Lestari Sri Rahayu, Malek Nik Ahmad Nizam Nik   +3 more
doaj   +1 more source

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis [PDF]

, 2017
Aims: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process.
Ceravolo, Graziela, Graham, Delyth, Harvey, Adam P., Hood, Katie Y., Lopes, Rheure A., Montezano, Augusto C., Rios, Francisco, Touyz, Rhian M.   +7 more
core   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Quantitative Insights into Collagen in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma using Picrosirius Red Stain [PDF]

Dental Journal of Advance Studies
Context: One of the predominant forms of cancer found in the oral cavity is squamous cell carcinoma. According to the records of the National Cancer Registry Programme, squamous cell carcinoma is the leading type of cancer affecting both men and women in
Kanika Sharma, Radheshyam Singh, Sumit S Sinha, Paramjit Singh, Neeraj Grover, Sanjeet Singh   +5 more
doaj   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury [PDF]

, 2014
Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. in this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the
Andrade-Oliveira, Vinicius, Braga, Tarcio Teodoro, Correa-Costa, Matheus, Felizardo, Raphael Jose Ferreira, Ioshie Hiyane, Meire, Midea Cuccovia, Iolanda, Regina Perez, Katia, Santana da Silva, Joao, Saraiva Camara, Niels Olsen   +8 more
core   +2 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Uso de quercetina a longo prazo em ratos cirróticos The long term use of quercetin in cirrhotic rats

Acta Cirúrgica Brasileira, 2003
OBJETIVO: Avaliar o uso a longo prazo do flavonóide quercetina em ratos cirróticos por ligadura de ducto biliar comum (LDB). MÉTODOS: Foram utilizados 32 ratos machos Wistar, sendo submetidos à LDB ou simulação, e distribuídos em 4 grupos: 1) controle, 2)
Aline Miltersteiner, Diego Miltersteiner, Nelson Pereira Filho, Aline Rolim Frota, Pedro Bins Ely, Cláudio Galeano Zettler, Cláudio Augusto Marroni, Norma P. Marroni   +7 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source