Results 181 to 190 of about 4,476 (243)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

The Role of Interleukin-23 and Interleukin-17 in Peri-Implant Crevicular Fluid of Subjects With Peri-Implant Disease: A Systematic Review. [PDF]

J Clin Lab Anal
Alarcón-Sánchez MA, Becerra-Ruiz JS, Rodríguez-Montaño R, Lomelí-Martínez SM, Escoto-Vasquez LS, Heboyan A.   +5 more
europepmc   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

The Wave-Particle Dualism of Photons as Seen from an Informational Point of View. [PDF]

Entropy (Basel)
Müller JG.
europepmc   +1 more source

Digital Professional Practice, Digital Competences and Impact on Family Support Services

Child &Family Social Work, EarlyView.
ABSTRACT Digital‐mediated practices in public social services require new strategies for administration, communication, assessment and intervention. Within this field, research framed under UNESCO's (2020) Media and Information Literacy model—examining digital media management and digital competence in information management, communication, digital ...
Guacimara Rodríguez, Sonia Byrne, Miriam Álvarez, Nauzet Gutiérrez‐Rodríguez, Sonia Padilla, Juan Carlos Martín, María José Rodrigo   +6 more
wiley   +1 more source

Excess fibroblast growth factor 23 in alcoholic osteomalacia is derived from the bone. [PDF]

JBMR Plus
Hidaka N, Oyama Y, Koga M, Kondo N, Yasunaga Y, Shimakura T, Yamamoto N, Takahashi HE, Iwafuchi Y, Watanabe S, Kimura S, Hoshino Y, Kato H, Kinoshita Y, Kobayashi H, Tanaka T, Ushiku T, Nangaku M, Tanaka S, Makita N, Saito T, Ito N.   +21 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies. [PDF]

Front Immunol
Porfireva ES, Zadorozhny AD, Rudik AV, Filimonov DA, Lagunin AA.   +4 more
europepmc   +1 more source

A wild‐caught rosy barb Pethia conchonius in a British urban pond underscores the need to prevent aquarium releases

Journal of Fish Biology, EarlyView.
Abstract A specimen of rosy barb Pethia conchonius of 51 mm standard length, encountered in an urban pond in London, is reported. This small cyprinid is native to lakes and streams in subtropical regions of southern Asia and is commonly sold as an ornamental fish.
Peter J. Barry, Phil I. Davison, Luke Pearson, Gordon H. Copp   +3 more
wiley   +1 more source

Insights in bone marrow failure syndromes: take home messages from the 3rd ESH-EBMT-EHA-IPIG translational research conference. [PDF]

Bone Marrow Transplant
Cacace F, Dicks MJ, Siliceo P.
europepmc   +1 more source