Results 111 to 120 of about 195,293 (306)

Una mirada actual al estado de la población en condición de discapacidad frente al uso de prótesis de miembro inferior a nivel transtibial

open access: yesInformador Técnico, 2017
En el Centro de Diseño y Metrología del SENA– CDM se ha detectado que la población en condición de discapacidad de miembros inferiores representa un desafío técnico y tecnológico en la recuperación de las condiciones normales de la marcha, puesto que se ...
Jhon Hernández Martin   +1 more
doaj   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang   +10 more
wiley   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

open access: yesAdvanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu   +9 more
wiley   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

open access: yesAdvanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang   +10 more
wiley   +1 more source

La beata Lucia Filippini : fondatrice e Superiora dell'Istituto delle Maestre Pie Filippini [PDF]

open access: yes, 1926
Marca tip. na portData de prelim., 1926Lám. en b. e n.
Salotti, Carlos
core  

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

open access: yesAdvanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding   +7 more
wiley   +1 more source

Who Gets Grandma's Yellow Pie Plate? Video [PDF]

open access: yes, 1999
Runtime 12:30 minutesUniversity of Minnesota, Extension Service. (1999). Who Gets Grandma's Yellow Pie Plate? Video.
University of Minnesota, Extension Service
core  

Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG

open access: yesAdvanced Science, EarlyView.
Simultaneous MEG and stereotactic EEG (SEEG) recordings provide a direct validation framework for MEG source imaging in focal epilepsy. Virtual SEEG signals derived from MEG reconstructions reveal significant agreement with intracranial measures of spike localization, resting‐state oscillations, and functional connectivity, while also identifying ...
Jawata Afnan   +10 more
wiley   +1 more source

Pie diabético y su relación con la hemoglobina glicosilada en pacientes con diabetes mellitus tipo 2 en el Centro de Salud número 1 de la ciudad de Ibarra, provincia de Imbabura, de septiembre a noviembre del 2016 [PDF]

open access: yes, 2016
La Diabetes Mellitus Tipo 2 es una enfermedad crónica relevante no solo por encontrarse dentro de las primeras causas de morbimortalidad sino también por las complicaciones micro y macrovasculares que presenta el paciente asociado a la hiperglicemia, al ...
Quelal Narváez, Rosa Liliana   +1 more
core   +2 more sources

Multiscale Spatial Fusion Feature‐Driven Characterization of Gastric Cancer Invasive Margins: A Multicenter Cohort Study for Preoperative Accurate Differentiation Between T4a and T4b Subtypes

open access: yesAdvanced Science, EarlyView.
This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.
Guoliang Zheng   +20 more
wiley   +1 more source

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