Results 121 to 130 of about 1,392,738 (297)

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

By pass distales al cuello de pie

Cirugía del Uruguay, 1997
Se analizan retrospectivamente los resultados de 48 puentes distales al cuello del pie realizados en 43 pacientes, 32 hombres y 11 mujeres, con una edad media de 70 años, en un período de 20 meses.
Carmelo Gastambide, Alejandro Esperón, Jorge Pereira, Juan J. Martín, Daniel López, Marcelo Diamant   +5 more
doaj  

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Luxación compleja de la articulación del Lisfranc y de Chopart

Cirugía del Uruguay, 2019
Presentado en sesión de 23  de octubre de ...
Gerardo Caprio
doaj  

Compromiso de las articulaciones vecinas en la evolución alejada de la artrodesis de tobillo

Revista de la Asociación Argentina de Ortopedia y Traumatología
Introducción: La artrodesis tibioastragalina es una opción para tratar la artrosis de tobillo en pacientes que no responden a las medidas conservadoras.
Alberto Macklin Vadell, Enzo Sperone, Andrés Bigatti, Matías Iglesias, Yanser Atilmis, Martín Rofrano, Stephanía Cruz, Emanuel Fedún Rodríguez   +7 more
doaj   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Tratamiento quirúrgico del pie plano

Cirugía del Uruguay, 1973
Presentamos una terapéutica quirúrgica del pie plano en nmos entre 8 y 14 años de edad en los cuales ha fa11ado el uso de plantares. El autor destaca la importancia de restaurar el alineamiento del retropié corrigiendo su valgo y la pronación además de ...
Selva Ruiz de Marella
doaj  

Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals

Advanced Science, EarlyView.
Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen, Wentong Tu, Tao Yu, Chao Chen, Zhixiang Zhang, Zhixiang Xie, Yingzhe Liu   +6 more
wiley   +1 more source

Tendinopatía insercional del tendón de Aquiles: tratamiento quirúrgico con anclajes en doble hilera. Serie de casos

Revista de la Asociación Argentina de Ortopedia y Traumatología
Introducción: La tendinopatía insercional del tendón de Aquiles que no mejora con un tratamiento conservador requiere cirugía. Uno de los tratamientos quirúrgicos es la resección de la exostosis retrocalcánea, el desbridamiento de las calcificaciones ...
Julieta Brué, Virginia María Cafruni, Ana Cecilia Parise, Julián Manuel Parma, Daniel Sebastián Villena, Leonardo Ángel Conti, N. Marina Carrasco, Pablo Sotelano, María Gala Santini Araujo   +8 more
doaj   +1 more source