Results 121 to 130 of about 1,464,600 (373)

The loss of *g before *m in Proto-Slavic [PDF]

open access: yes, 2010
This paper proposes a new sound rule for Proto-Slavic, according to which *g (from PIE *g, *gw, *gh, and *gwh) was lost before *m. This development was posterior to Winter’s law and the merger of voiced and aspirated stop in Slavic.
Matasović, Ranko
core  

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

open access: yesAdvanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian   +5 more
wiley   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

open access: yesAdvanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei   +12 more
wiley   +1 more source

Two-person pie-cutting: The fairest cuts [PDF]

open access: yes
Barbanel, Brams, and Stromquist (2009) asked whether there exists a two-person moving-knife procedure that yields an envy-free, undominated, and equitable allocation of a pie.
Barbanel, Julius B., Brams, Steven J.
core   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

Pastiche [PDF]

open access: yes, 2014
The term "pastiche" originally means a "pasty" or "pie" dish containing several different ingredients. It has come to be used synonymously with a variety of terms whose meanings are rarely fixed with clarity: parody, montage, quotation, allusion, irony ...
Weiser, Peg Zeglin Brand
core  

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li   +22 more
wiley   +1 more source

Portable inference engine: An extended CLIPS for real-time production systems [PDF]

open access: yes
The present C-Language Integrated Production System (CLIPS) architecture has not been optimized to deal with the constraints of real-time production systems.
Homeier, Peter, Le, Thach
core   +1 more source

Comparación de la actividad de determinados músculos del tronco y extremidades inferiores en la marcha de mujeres jóvenes con pie en supinación, pronación y neutro [PDF]

open access: yes, 2016
  Los cambios en la estructura anatómica del pie reducen su capacidad de funcionamiento normal. Este estudio tuvo por objetivo comparar determinados músculos del tronco y de las extremidades inferiores durante la marcha en individuos con distintos tipos ...
Anbarian, Mehrdad   +3 more
core  

HIDF: Integrating Tree‐Structured scRNA‐seq Heterogeneity for Hierarchical Deconvolution of Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
The prevailing neglect of cellular hierarchies in current spatial transcriptomics deconvolution often obscures cellular heterogeneity and impedes the identification of fine‐grained subtypes. To address this issue, HIDF employs a cluster‐tree and dual regularization to systematically model cellular hierarchical structures.
Zhiyi Zou   +5 more
wiley   +1 more source

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