Results 111 to 120 of about 57,803 (192)

Decoding temporal miRNA signatures of semen under in vitro exposure for forensic time since deposition estimation using machine learning‐driven modeling

Interdisciplinary Medicine, EarlyView.
This study develops a novel miRNA‐based framework for estimating the time since deposition of semen stains, combining small RNA sequencing with machine learning. Time‐dependent miRNA modules were identified using Mfuzz clustering and WGCNA, followed by a multi‐stage feature selection pipeline that reduced 261 candidate miRNAs to a minimal 7‐miRNA panel.
Meiming Cai, Qiong Lan, Tong Xie, Qinglin Liu, Ming Zhao, Xiaolian Wu, Xin Shi, Ruonan Shen, Yiman Wu, Chen Mao, Bin Cong, Bofeng Zhu   +11 more
wiley   +1 more source

Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV-idence? [PDF]

JOR Spine
Corraini D, Voskamp C, Wauben MHM, Tryfonidou MA.   +3 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Memory B cell development in response to mRNA SARS-CoV-2 and nanoparticle immunization in mice. [PDF]

Proc Natl Acad Sci U S A
Wiatr M, Wang Z, Canis M, Hernandez B, Gazumyan A, Santos GSS, Shawraz S, Lee S, Bieniasz PD, Hatziioannou T, Muecksch F, Nussenzweig MC.   +11 more
europepmc   +1 more source

Therapeutic Options for IgA Pemphigus in Patients Refractory to Dapsone

JEADV Clinical Practice, EarlyView.
ABSTRACT IgA pemphigus is a rare autoimmune blistering disorder with limited therapeutic guidance available due to its rarity and complex presentation. This comprehensive analysis evaluates the therapeutic outcomes of 67 published patients, emphasising the significant role of dapsone as the first‐line treatment.
Lorenz Frasheri, Marta Dechant, Tilo Biedermann   +2 more
wiley   +1 more source

Systemic and airway T cell dynamics with influenza-specific immune recovery by cystic fibrosis elexacaftor/tezacaftor/ivacaftor therapy. [PDF]

Respir Res
Mouchtaridi E, Kowalik A, Raineri EJM, Humbert M, Jägerstedt J, Bojarlind M, Nilsson K, Flodström-Tullberg M, Pincikova T, Sandberg JK.   +9 more
europepmc   +1 more source

Hemodynamic Significance of APEXCT Coronary Angiography Combined With Dynamic CT Myocardial Perfusion Imaging in Assessing Restenosis After Coronary Stenting

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to evaluate the hemodynamic significance of in‐stent restenosis (ISR) by using a combined anatomical‐functional approach with photon‐counting CT coronary angiography (APEX‐CT CTA) and dynamic CT myocardial perfusion imaging (CT‐MPI). We prospectively enrolled 239 symptomatic patients at least 9 months after PCI.
Liang‐Shi Wang, Tian Bai, Ji‐Zhou Yan, Peng‐Yu Guan, Li‐Juan Wen, Hong Guo, Tian‐Yu Zhang   +6 more
wiley   +1 more source

Recent Advances in the Laser‐Based Fabrication and Applications of High‐Entropy Alloy Nanoparticles

MetalMat, EarlyView.
This review presents recent advances in the laser‐based fabrication of high‐entropy alloy nanoparticles, focusing on scalable, environmentally friendly, and compositionally tunable synthesis methods. It highlights the critical influence of laser parameters on nanoparticle size, phase, and morphology, enabling tailored properties for applications in ...
Bibek Kumar Singh, Rajesh Rawat, Archana Tiwari, Venugopal Rao Soma, Ajay Tripathi   +4 more
wiley   +1 more source

Gastrointestinal MAIT cells in chronic HIV-1 infection. [PDF]

J Immunol
Ferre AL, Fehrman EA, Hunt PW, Somsouk M, Hoh R, Eller MA, Paquin-Proulx D, Sandberg JK, Shacklett BL.   +8 more
europepmc   +1 more source

Mesoscale Whole‐Brain T2*‐Weighted and Associated Quantitative MRI in Humans at 10.5 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To demonstrate mesoscale whole‐brain T2*‐weighted (T2*w) MRI at 10.5 T, quantify R2* relaxation rate and magnetic susceptibility (χ), and evaluate T2*w contrast at such high field strength. Methods Multi‐echo GRE (ME‐GRE) data were collected in healthy adults at 0.5 mm isotropic resolution at 10.5 T.
Jiaen Liu, Peter van Gelderen, Jacco A. de Zwart, Jeff H. Duyn, Yujia Huang, Shuxian Qu, Andrea Grant, Edward J. Auerbach, Matt Waks, Russell L. Lagore, Lance Delabarre, Alireza Sadeghi‐Tarakameh, Yigitcan Eryaman, Gregor Adriany, Kamil Uğurbil, Xiaoping Wu   +15 more
wiley   +1 more source