Results 201 to 210 of about 4,923,870 (255)

Target site selection and P1 engineering enable highly efficient circular RNA production via end-to-end self-targeting and splicing. [PDF]

Nucleic Acids Res
Lee KH, Kim S, Cha J, Lee SW.
europepmc   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

PACS1 syndrome variant alters the proteomic landscape of developing cortical organoids. [PDF]

iScience
Gomez-Maqueo X, Rylaarsdam LE, Woo A, Schroder AL, Rakotomamonjy J, Bossert CL, Smith TA, Ruiz S, Gilardi J, Klei L, Devlin B, MacDonald ML, Guemez-Gamboa A.   +12 more
europepmc   +1 more source

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source

The impact of ABO blood groups and RhD status on systemic inflammation markers (Systemic Immune-Inflammation Index, Systemic Inflammation Response Index, and Pan-Immune-Inflammation Value) in a large cohort of healthy adults. [PDF]

Lab Med
Avci AO.
europepmc   +1 more source

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

Nutraceutical Benefits of Anchomanes difformis Rhizome and Its Effects on Blood Glucose and Hepatorenal Function in Normoglycemic Rats

Food Chemistry International, EarlyView.
Scientific analysis of Anchomanes difformis roots confirms significant nutraceutical potential, containing high levels of carbohydrates, proteins, and essential minerals. Phytochemical screening revealed antioxidants such as phenols and flavonoids, and although the extracts effectively lowered plasma glucose, safety testing showed dose‐dependent risks.
Lawrence Folorunso Dada, Kingsley Omage, Marshall Arebojie Azeke   +2 more
wiley   +1 more source

Protein-dependent CD4⁺ T cell specialization and CD8⁺ T cell-driven IL-2 production in HIV. [PDF]

iScience
Pušnik J, Heinemann FM, Heinold A, Richter E, Esser S, Streeck H.   +5 more
europepmc   +1 more source

Mapping Regioisomer-Dependent Buchwald-Hartwig C-N Coupling: Bromoimidazo[1,5-a]pyridines as a Model Electrophile Series. [PDF]

Molecules
Sotnik SO, Stetsenko SV, Pavliei IM, Brusylovets OA, Pokholenko OA, Grabchuk GP, Pashenko OY, Volochnyuk DM, Ryabukhin SV.   +8 more
europepmc   +1 more source