Results 121 to 130 of about 10,071 (256)

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

PIEZO1-HaloTag hiPSC Lines: Novel Resource for Visualizing Endogenous PIEZO1 from Single Cells to Tissue Organoids

Mechanical forces, originating both intracellularly and extracellularly, must be transduced into biological signals through a process known as mechanotransduction.
Bertaccini, Gabriella Adrianna
core   +1 more source

Piezo1-mediated autophagy promotes immune-inflammatory responses in ankylosing spondylitis

Cell Death and Disease
This study aimed to investigate the role of Piezo1 in the immune-inflammatory response during the pathogenesis of ankylosing spondylitis (AS) and its underlying mechanisms.
Hui Zhao, Xueying Yu, Minxin Jiang, Ziqi Li, Yanyu Zhao, Yuxin Ren, Lanlan Fang, Mengmeng Wang, Xiaofeng Lu, Yubo Ma, Guosheng Wang, Qiang Zhou, Yanfeng Zou, Guoqi Cai, Faming Pan   +14 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal

Hematopoietic stem cells surrender organelles during differentiation, leaving mature red blood cells (RBC) devoid of transcriptional machinery and mitochondria.
Kuck, Lennart, McNamee, Antony P, Peart, Jason N, Sadafi, Ario, Marr, Carsten, Bordukova, Maria, Simmonds, Michael J   +6 more
core   +1 more source

Osteolectin/CLEC11A‐Related Signaling Molecules in Periodontitis and Peri‐Implantitis

Oral Diseases, EarlyView.
ABSTRACT Objective Periodontal and peri‐implant tissues differ histologically and biomechanically, which may be reflected in local osteogenic and mechanosensitive signaling. This exploratory cross‐sectional study aimed to compare expression profiles of Osteolectin (CLEC11A) and related signaling molecules across periodontal health, peri‐implant health,
Gözde Işıker Kara, Feyzanur Caldiran, Hatice Balci Yuce, Busenur Sahin, Ercan Cacan   +4 more
wiley   +1 more source

Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway

Communications Biology
Necrotizing enterocolitis (NEC) is a devastating inflammatory bowel necrosis of preterm infants with limited therapeutic approaches. Mounting evidence supports the role of Piezo1, namely, a widely distributed mechanosensor in intestinal epithelial cells (
Zhenyu Li, Qinlei Jiang, Jiaqi Wei, Dan Dang, Zhaoli Meng, Hui Wu   +5 more
doaj   +1 more source

Orthopedic Mechanophenotype: A Structured Narrative Review of Multiscale Biomechanics, Mechanotransduction, and Clinical Decision‐Making

Orthopaedic Surgery, EarlyView.
The orthopedic mechanophenotype framework comprises load exposure, tissue susceptibility, and biological adaptability axes to decode mechanical‐biological crosstalk. It guides clinical phenotyping, targeted intervention, and response monitoring for orthopedic disorders beyond static morphological assessment.
Zihao Lan, Zhipeng Mu, Hongjian Li
wiley   +1 more source

Activation of WNK1 signaling through Piezo1

Proceedings of the National Academy of Sciences
With No lysine (K) 1 (WNK1) is essential for ion and volume homeostasis, sensing osmotic stress and activating pathways that regulate ion transport. Its response to osmotic stress shares similarities with the function of the mechanosensitive ion channel Piezo1.
Ji-Ung Jung, Steve Stippec, Melanie H. Cobb   +2 more
openaire   +2 more sources

Cerebrovascular flow‐mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations

Experimental Physiology, EarlyView.
Abstract Arterial shear‐mediated vasodilation is a well‐established measure of endothelial function and serves as a critical biomarker for cardiovascular disease risk. Endothelial function can be measured using a variety of experimental methodologies; however, the most widely adopted technique is ultrasound‐based flow‐mediated dilation (FMD), in which ...
Yi Zhen Bao, Tabitha V. Craig, Jenna C. McCrone, Kurt J. Smith, Michael M. Tymko   +4 more
wiley   +1 more source