Results 131 to 140 of about 10,071 (256)

Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction

Renal Failure
Renal fibrosis is the major pathological changes of Chronic kidney disease (CKD). Piezo1, a mechanical sensitive ion channel, is implicated in organ fibrosis. However, the precise role of Piezo1 in CKD fibrosis is unknown.
Yanping Zhang, Lei Lv, Zhaokai Zhou, He Zhang, Qi Li, Shuai Yang, Yibo Wen, Qingwei Wang, Jinjin Feng, Wei Lu, Wei Jia, Jian Guo Wen   +11 more
doaj   +1 more source

Role of the mechanotransductor PIEZO1 in megakaryocyte differentiation

Journal of Cellular and Molecular Medicine
AbstractFrom haematopoietic stem cells to megakaryocytes (Mks), cells undergo various mechanical forces that affect Mk differentiation, maturation and proplatelet formation. The mechanotransductor PIEZO1 appears to be a natural candidate for sensing these mechanical forces and regulating megakaryopoiesis and thrombopoiesis.
Demagny, Julien, Poirault-Chassac, Sonia, Ilsaint, Damtz Nehemie, Marchelli, Aurore, Gomila, Cathy, Ouled-Haddou, Hakim, Collet, Louison, Le Guyader, Maïlys, Gaussem, Pascale, Garçon, Loïc, Bachelot-Loza, Christilla   +10 more
openaire   +3 more sources

The cold‐water immersion recovery–adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation

Experimental Physiology, EarlyView.
Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera, Jose Lozano‐Meca, Miguel López‐Moreno, Edgar Simón Sancho‐Haro, Mario Muñoz‐López, Eneko Baz‐Valle, José Francisco López‐Gil, Rodrigo Yáñez‐Sepúlveda, Vicente Javier Clemente‐Suárez   +8 more
wiley   +1 more source

Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway

Bone Research
Piezo1, a key mechanosensor in bone homeostasis, plays a crucial role in fracture healing. However, the mechanisms through which Piezo1 regulates chondrocytes and affects endochondral ossification remain poorly understood. This study aimed to investigate
Tao Zhang, Hongzhi Lv, Siming Jia, Lijun Wang, Weijian Liu, Kai Ding, Xiaofeng Du, Guangzhao Hou, Zhiyong Hou, Yingze Zhang, Weiguo Zou, Wei Chen, Yanbin Zhu   +12 more
doaj   +1 more source

Piezo1 protects against inflammatory bone loss via a unique Ca2+-independent mechanism in osteoclasts

Frontiers in Immunology
IntroductionBone integrity relies on mechanical stimulation, and its absence, such as in disuse osteoporosis or periodontitis, enhances osteoclast-mediated resorption.
Satoru Shindo, Shin Nakamura, Avery Hawthorne, Alireza Heidari, Maria Rita Pastore, Motoki Okamoto, Maiko Suzuki, Manuel Salinas, Takumi Memida, Dmitriy Minond, Alexander Bontempo, Mark Cayabyab, Mark Cayabyab, Yingzi Yang, Janet L Crane, Janet L Crane, Maria Hernandez, Saynur Vardar, Patrick Hardigan, Patrick Hardigan, Xiaozhe Han, Xiaozhe Han, Steven Kaltman, Toshihisa Kawai, Toshihisa Kawai   +24 more
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Pressure‐sensing Piezo1: the eyes have it [PDF]

The Journal of Physiology, 2020
Sandip M. Swain, Rodger A. Liddle
openaire   +2 more sources

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro

Frontiers in Molecular Neuroscience
IntroductionDysfunction of the enteric nervous system (ENS) is linked to a myriad of gastrointestinal (GI) disorders. Piezo1 is a mechanosensitive ion channel found throughout the GI tract, but its role in the ENS is largely unknown.
Chioma Moneme, Oluyinka O. Olutoye, Michał F. Sobstel, Yuwen Zhang, Xinyu Zhou, Jacob L. Kaminer, Britney A. Hsu, Chengli Shen, Arabinda Mandal, Hui Li, Hui Li, Ling Yu, Ling Yu, Swathi Balaji, Swathi Balaji, Sundeep G. Keswani, Sundeep G. Keswani, Lily S. Cheng, Lily S. Cheng, Lily S. Cheng   +19 more
doaj   +1 more source

PIEZO1 drives trophoblast fusion and placental development

Nature Communications
Abstract PIEZO1, a mechanosensor 1,2 in endothelial cells, plays a critical role in fetal vascular development during embryogenesis 3,4 . However, its expression and function in placental trophoblasts remain unexplored.
Yang Zhang, Ke Z. Shan, Pengfei Liang, Augustus J. Lowry, Liping Feng, Huanghe Yang   +5 more
openaire   +3 more sources