Results 151 to 160 of about 11,131 (244)
Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress
Advanced Genetics, Volume 7, Issue 1, March 2026.Mechanical stress‐induced oxidative stress is a universal challenge across species, triggering a conserved antioxidant defense strategy. This perspective delves into the molecular evolutionary logic of this response, comparing mechanisms across plants, microorganisms, and animals to reveal their profound phylogenetic significance.
Feixiang Zhu, Kai Huang
wiley +1 more source
From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management
JCC Plus, Volume 1, Issue 2, March 2026.Important limitations exist in the current pharmacological landscape of Inflammatory Bowel Disease (IBD), such as variable response rates and treatment‐limiting adverse effects. In this review, we perform a critical assessment of the current literature on novel multimodal biophysical approaches showing alternative mechanisms of action to, and potential
Benedetta Ricchi +7 more
wiley +1 more source
Frontiers in ImmunologyIntroductionBone integrity relies on mechanical stimulation, and its absence, such as in disuse osteoporosis or periodontitis, enhances osteoclast-mediated resorption.
Satoru Shindo +24 more
doaj +1 more source
Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats [PDF]
Master of ScienceDepartment of KinesiologySteven CoppMechanical and metabolic signals arising during skeletal muscle contraction reflexly increase sympathetic nerve activity and blood pressure (i.e., the exercise pressor reflex).
Kempf, Evan Alexander
core
Mechanosensitive Cell‐Laden Shape‐Memory Scaffolds Engineered via Cryogelation
Small Structures, Volume 7, Issue 3, March 2026.GelMA‐based shape‐memory scaffolds encapsulating human adipose‐derived stem cells are fabricated via cryogelation, showing rapid recovery and high cell viability. Under cyclic compression, they promoted mechanotransduction gene expression, and composite formulations (collagen/GelMA, dECM/GelMA) retained robust shape‐memory, highlighting their promise ...
JaeYoon Lee +4 more
wiley +1 more source
Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
Open MedicinePhotothermal therapy (PTT) of nanomaterials is an emerging novel therapeutic strategy for breast cancer. However, there exists an urgent need for appropriate strategies to enhance the antitumor efficacy of PTT and minimize damage to surrounding normal ...
Wang Shao-kang +13 more
doaj +1 more source
Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro
Frontiers in Molecular NeuroscienceIntroductionDysfunction of the enteric nervous system (ENS) is linked to a myriad of gastrointestinal (GI) disorders. Piezo1 is a mechanosensitive ion channel found throughout the GI tract, but its role in the ENS is largely unknown.
Chioma Moneme +19 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.(A) CD47, acting in a cis‐manner with integrins, promotes myoblast fusion. TSP‐1 serves as a bridging molecule for these proteins to recognize PS on the surface of the other fusing myoblasts. (B) Blocking of these signals by neutralizing antibodies reduces cell fusion. Inhibition of PIEZO1 activity by constantly expressed PS on apoptotic cells leads to
Maysaa Adil Ali +10 more
wiley +1 more source
Advanced Materials InterfacesLung diseases are one of the leading causes of global mortality. Advances in induced pluripotent stem cell (iPSC) differentiation have enabled the creation of bronchiolar and alveolar lung organoids, advancing research on lung conditions.
Junyao Zhang +9 more
doaj +1 more source