Results 161 to 170 of about 10,071 (256)

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Piezo1-mediated mechanotransduction in bone formation and fracture repair. [PDF]

Biochem Biophys Rep
Wu R, Zhuang Y, Yang H, Dong Q, Wang S, Zhang J, Chen Y.   +6 more
europepmc   +1 more source

Mechanical force receptor Piezo1 regulates TH9 cell differentiation

Summary: Interleukin (IL)-9-producing CD4+ T cells (TH9) are essential for mediating antitumor immunity, but the mechanisms of TH9 cell differentiation remain unclear.
Yujing Bi, Guangwei Liu, Yejin Cao, Qiuli Yang, Yingjie Dong, Longhao Zhao, Likun Wang, Zi Geng   +7 more
core   +1 more source

Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Multiorgan fibrosis arises when chronic injury activates fibroblasts and remodels extracellular matrix, whose increasing stiffness sustains disease through mechanotransduction pathways. Bidirectional cellular‐matrix feedback operates across lung, heart, liver, and kidney.
Amedeo Lonardo, Ralf Weiskirchen
wiley   +1 more source

Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling. [PDF]

Int J Oral Sci
Nie X, Huang K, Chu E, Chung MK.
europepmc   +1 more source

Myelin sheath lengths in the central nervous system scale to axon diameter via oligodendroglial Piezo1. [PDF]

PLoS Biol
Young AR, Galfano A, Reyngoudt J, Lewis RW, Cash M, Polis B, Zalusky M, Datta A, Bechler ME.   +8 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Piezo1-mediated Mechanotransduction in the musculoskeletal system: Signaling networks and therapeutic perspectives. [PDF]

Bone Rep
Zhao H, Huang J, Tan Y, Shen S, Ying Z, Li Z, Xiong Y, Ge H, Wang X, Zhan H, Shen Y, Du G.   +11 more
europepmc   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis. [PDF]

Cells
Toumi H, Almhdie-Imjabbar A, Lespessailles E.   +2 more
europepmc   +1 more source