Results 211 to 220 of about 11,131 (244)

PIEZO1 discriminates mechanical stimuli

SSRN Electronic Journal, 2022
AbstractPIEZO1 channels open in response to numerous mechanical stimuli, such as physical membrane deformations, which modulate the curvature of flexible domains called blades. Yet, whether different stimuli cause similar blade motions and whether these rearrangements correlate with pore opening remain unclear.
Alper D. Ozkan, Tharaka D. Wijerathne, Tina Gettas, Jérôme J. Lacroix   +3 more
openaire   +1 more source

Force-induced conformational changes in PIEZO1 [PDF]

Nature, 2019
PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms. Here we use cryo-electron microscopy to show that PIEZO1 adopts different degrees of curvature in lipid vesicles of different sizes.
Yi-Chih Lin, Yusong R Guo, Atsushi Miyagi   +2 more
exaly   +3 more sources

PIEZO1, sensing the touch during erythropoiesis

Current Opinion in Hematology, 2022
Purpose of review Awarding the 2021 Nobel to Ardem Patapoutian for the discovery of the PIEZO mechanotransducers has emphasized the importance of touch-sensing mechanisms in cell physiology. It is well known that PIEZO1 is expressed at the surface of red blood cells where it adjusts their hydration status under mechanical ...
Caulier, Alexis, Garcon, Loic
openaire   +2 more sources

Amphipathic molecules modulate PIEZO1 activity

Biochemical Society Transactions, 2019
PIEZO proteins are large eukaryotic mechanically-gated channels that function as homotrimers. The basic PIEZO1 structure has been elucidated by CryoEM and it assembles into a protein–lipid dome. A curved lipid region allows for the transition to the lipid bilayer from the dome (footprint).
Charles D. Cox, Philip A. Gottlieb
openaire   +2 more sources

PIEZO1 promotes inflammation

Science Signaling, 2019
Myeloid cells respond to mechanical force through the ion channel PIEZO1, which promotes their proinflammatory response.
openaire   +1 more source

Piezo1-dependent regulation of urinary osmolarity

Pflügers Archiv - European Journal of Physiology, 2016
The collecting duct (CD) is the final segment of the kidney involved in the fine regulation of osmotic and ionic balance. During dehydration, arginine vasopressin (AVP) stimulates the expression and trafficking of aquaporin 2 (AQP2) to the apical membrane of CD principal cells, thereby allowing water reabsorption from the primary urine.
Joana Raquel, Martins, David, Penton, Rémi, Peyronnet, Malika, Arhatte, Céline, Moro, Nicolas, Picard, Birgül, Kurt, Amanda, Patel, Eric, Honoré, Sophie, Demolombe   +9 more
openaire   +2 more sources

PIEZO1 mediates a mechanothrombotic pathway in diabetes

Science Translational Medicine, 2022
Hematopoietic cell selection based on PIEZO1 expression drives thrombosis risk in type 2 diabetes.
Wandi Zhu, Shihui Guo, Max Homilius, Cissy Nsubuga, Shane H. Wright, Dajun Quan, Ashmita KC, Samuel S. Eddy, Rachelle A. Victorio, Manu Beerens, Robert Flaumenhaft, Rahul C. Deo, Calum A. MacRae   +12 more
openaire   +2 more sources

Architecture of the mammalian mechanosensitive Piezo1 channel

Nature, 2015
Piezo proteins are evolutionarily conserved and functionally diverse mechanosensitive cation channels. However, the overall structural architecture and gating mechanisms of Piezo channels have remained unknown. Here we determine the cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 Å.
Jingpeng Ge, Ningning Li, Ning Gao
exaly   +3 more sources

Activation of Piezo1 Inhibits Kidney Cystogenesis

AbstractThe disruption of calcium signaling associated with polycystin deficiency has been proposed as the primary event underlying the increased abnormally patterned epithelial cell growth characteristic of Polycystic Kidney Disease. Calcium can be regulated through mechanotransduction, and the mechanosensitive cation channel Piezo1 has been ...
Qingfeng Fan, Mohamad Hadla, Zack Peterson, Grace Nelson, Hong Ye, Xiaofang Wang, Jean Marc Mardirossian, Peter C. Harris, Seth L. Alper, Y.S. Prakash, Arthur Beyder, Vicente E. Torres, Fouad T. Chebib   +12 more
openaire   +2 more sources

Piezo1 and Piezo2 collectively regulate jawbone development

Development
ABSTRACT Piezo1 and Piezo2 are recently reported mechanosensory ion channels that transduce mechanical stimuli from the environment into intracellular biochemical signals in various tissues and organ systems. Here, we show that Piezo1 and Piezo2 display a robust expression during jawbone development.
Xuguang Nie, Yasaman Abbasi, Man-Kyo Chung   +2 more
openaire   +2 more sources