Results 221 to 230 of about 10,071 (256)

PIEZO1 discriminates mechanical stimuli

SSRN Electronic Journal, 2022
Abstract PIEZO1 channels open in response to numerous mechanical stimuli, such as physical membrane deformations, which modulate the curvature of flexible domains called blades. Yet, whether different stimuli cause similar blade motions and whether these rearrangements correlate with pore opening remain unclear.
Alper D. Ozkan, Tharaka D. Wijerathne, Tina Gettas, Jérôme J. Lacroix   +3 more
openaire   +1 more source

PIEZO1 mediates a mechanothrombotic pathway in diabetes

Science Translational Medicine, 2022
Hematopoietic cell selection based on PIEZO1 expression drives thrombosis risk in type 2 diabetes.
Wandi Zhu, Shihui Guo, Max Homilius, Cissy Nsubuga, Shane H. Wright, Dajun Quan, Ashmita KC, Samuel S. Eddy, Rachelle A. Victorio, Manu Beerens, Robert Flaumenhaft, Rahul C. Deo, Calum A. MacRae   +12 more
openaire   +2 more sources

PIEZO1, sensing the touch during erythropoiesis

Current Opinion in Hematology, 2022
Purpose of review Awarding the 2021 Nobel to Ardem Patapoutian for the discovery of the PIEZO mechanotransducers has emphasized the importance of touch-sensing mechanisms in cell physiology. It is well known that PIEZO1 is expressed at the surface of red blood cells where it adjusts their hydration status under mechanical ...
Caulier, Alexis, Garcon, Loic
openaire   +2 more sources

The role of mechanosensitive Piezo1 channel in diseases

Progress in Biophysics and Molecular Biology, 2022
Mechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation ...
Siqi Song, Hong Zhang, Xiaoya Wang, Wei Chen, Wenxuan Cao, Zhe Zhang, Chunying Shi   +6 more
openaire   +2 more sources

Architecture of the mammalian mechanosensitive Piezo1 channel

Nature, 2015
Piezo proteins are evolutionarily conserved and functionally diverse mechanosensitive cation channels. However, the overall structural architecture and gating mechanisms of Piezo channels have remained unknown. Here we determine the cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 Å.
Jingpeng, Ge, Wanqiu, Li, Qiancheng, Zhao, Ningning, Li, Maofei, Chen, Peng, Zhi, Ruochong, Li, Ning, Gao, Bailong, Xiao, Maojun, Yang   +9 more
openaire   +2 more sources

PIEZO1 promotes inflammation

Science Signaling, 2019
Myeloid cells respond to mechanical force through the ion channel PIEZO1, which promotes their proinflammatory response.
openaire   +1 more source

The Structural Basis for Sensing by the Piezo1 Protein

2017
Mechanotransduction is one of the processes by which cells sense and convert mechanical stimuli into biological signals. Experimental data from various species have revealed crucial roles for mechanotransduction in organ development and a plethora of physiological activities.
W, Li, N, Gao, M, Yang
openaire   +2 more sources

Amphipathic molecules modulate PIEZO1 activity

Biochemical Society Transactions, 2019
PIEZO proteins are large eukaryotic mechanically-gated channels that function as homotrimers. The basic PIEZO1 structure has been elucidated by CryoEM and it assembles into a protein–lipid dome. A curved lipid region allows for the transition to the lipid bilayer from the dome (footprint).
Charles D. Cox, Philip A. Gottlieb
openaire   +2 more sources

The biophysics of piezo1 and piezo2 mechanosensitive channels

Biophysical Chemistry, 2016
The ability to sense mechanical stimuli and elaborate a response to them is a fundamental process in all organisms, driving crucial mechanisms ranging from cell volume regulation up to organ development or regeneration. Nevertheless, only in few cases the underlying molecular players are known.
Soattin L, Fiore M, Gavazzo P, Viti F, Facci P, Raiteri R, Difato F, Pusch M, Vassalli M   +8 more
openaire   +5 more sources

Structure and mechanogating mechanism of the Piezo1 channel

Nature, 2018
The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here we determine the three-bladed, propeller-like electron cryo-microscopy structure of mouse Piezo1 and functionally reveal its mechanotransduction components.
Qiancheng, Zhao, Heng, Zhou, Shaopeng, Chi, Yanfeng, Wang, Jianhua, Wang, Jie, Geng, Kun, Wu, Wenhao, Liu, Tingxin, Zhang, Meng-Qiu, Dong, Jiawei, Wang, Xueming, Li, Bailong, Xiao   +12 more
openaire   +2 more sources