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Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction
2017Mutations in the genes encoding the mechanosensitive cation channels PIEZO1 and PIEZO2 are responsible for multiple hereditary human diseases. Loss-of-function mutations in the human PIEZO1 gene cause autosomal recessive congenital lymphatic dysplasia.
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Mechanosensing by Piezo1 and its implications in the kidney
Acta PhysiologicaAbstractPiezo1 is an essential mechanosensitive transduction ion channel in mammals. Its unique structure makes it capable of converting mechanical cues into electrical and biological signals, modulating biological and (patho)physiological processes in a wide variety of cells.
Xi Yuan +3 more
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Activation of Piezo1 Inhibits Kidney Cystogenesis
Abstract The disruption of calcium signaling associated with polycystin deficiency has been proposed as the primary event underlying the increased abnormally patterned epithelial cell growth characteristic of Polycystic Kidney Disease.Qingfeng Fan +12 more
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PIEZO1 polymorphisms and bone mineral density
Bone, 2020Sora, Yasri, Viroj, Wiwanitkit
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Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease
Neuron, 2023Zhu Hongrui, Wei Mo, Sifang Chen
exaly
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
Biological Reviews, 2022Anthony Jaworowski +2 more
exaly
Proceedings of the National Academy of Sciences of the United States of America, 2021
Farshid Guilak, Yong Chen, Whasil Lee
exaly
Farshid Guilak, Yong Chen, Whasil Lee
exaly
Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix
ACS Applied Materials & Interfaces, 2022Khashayar Khoshmanesh +2 more
exaly