Results 61 to 70 of about 11,131 (244)

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

Bone Research
To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be elucidated. Here, Piezo1 channel was identified as a key iron transporter in response to mechanical stress.
Ziqian Xiang, Pengfei Zhang, Chunwang Jia, Rongkun Xu, Dingren Cao, Zhaoning Xu, Tingting Lu, Jingwei Liu, Xiaoxiong Wang, Cheng Qiu, Wenyang Fu, Weiwei Li, Lei Cheng, Qiang Yang, Shiqing Feng, Lianlei Wang, Yunpeng Zhao, Xinyu Liu   +17 more
doaj   +1 more source

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor [PDF]

, 2017
Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts are in short supply, and can be associated with pain and donor-site morbidity.
Biggs, Manus J. P., Blackburn, Gavin, Burgess, Karl, Childs, Peter G., Curtis, Adam S. G., Dalby, Matthew J., González-García, Cristina, Jayawarna, Vineetha, Orapiriyakul, Wich, Pemberton, Gabriel D., Reid, Stuart, Salmerón-Sánchez, Manuel, Thomas, Dilip, Tsimbouri, Penelope M., Vallejo-Giraldo, Catalina, Yang, Jingli   +15 more
core   +2 more sources

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels [PDF]

Cell Reports, 2020
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium, we considered if sphingomyelinase is relevant to endogenous PIEZO1. Patch clamping was used to quantify PIEZO1-
Shi, J, Hyman, AJ, De Vecchis, D, Chong, J, Lichtenstein, L, Futers, TS, Rouahi, M, Salvayre, AN, Auge, N, Kalli, AC, Beech, DJ   +10 more
openaire   +4 more sources

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Single mechanosensitive and ca(2+)-sensitive channel currents recorded from mouse and human embryonic stem cells [PDF]

, 2015
Cell-attached and inside-out patch clamp recording was used to compare the functional expression of membrane ion channels in mouse and human embryonic stem cells (ESCs). Both ESCs express mechanosensitive Ca(2+) permeant cation channels (MscCa) and large
Hamill, Owen P., Hmadcha, Abdelkrim, Navas, Sergio, Soria Escoms, Bernat   +3 more
core   +2 more sources

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science
Elevated expression of the mechanosensitive ion channel PIEZO1 in response to abnormal mechanical stimuli is implicated in many diseases, including myocardial infarction (MI).
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
doaj   +1 more source

Piezo1 Affects Temporomandibular Joint Osteoarthritis by Influencing pSmad3

Frontiers in Physiology, 2022
Objective: The aim of this research was to study the expression of Piezo1 in a rat temporomandibular joint osteoarthritis animal model and to explore its mechanism for inducing inflammatory changes.Methods: A total of 24male SD rats aged approximately 8 ...
Chuan-Bin Wu, Tie Ma, Lin Ma, Qiang Wang, Qing Zhou   +4 more
doaj   +1 more source

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels [PDF]

, 2016
The bacterial mechanosensitive channel MscL gates in response to membrane tension as a result of mechanical force transmitted directly to the channel from the lipid bilayer.
Bavi, Navid, Bavi, Omid, Corry, Ben, Cortes, D. Marien, Cox, Charles D., Deitmer, Joachim W., Hill, Adam P., Liu, Weihong, Martinac, Boris, Perozo, Eduardo, Rees, Douglas, Rohde, Paul R., Strop, Pavel   +12 more
core   +2 more sources

Functional Heteromeric PIEZO1 Ion Channels [PDF]

Biophysical Journal, 2016
Eukaryotic PIEZO1 ion channels are cation selective and open with membrane tension. The channel is further characterized by voltage dependent inactivation and a conductance of ∼45 pS. We mutated the glutamic acid at position 2117 to an aspartic acid and this increased channel conductance to 72 pS.
Gottlieb, Philip, Bae, Chilman, Gnanasambandam, Radakrishnan, Sachs, Frederick   +3 more
openaire   +1 more source