Results 141 to 150 of about 4,014 (160)

Functional and molecular diversity of human C-fibers in pain modulation. [PDF]

open access: yesCurr Opin Support Palliat Care
Barakat A   +4 more
europepmc   +1 more source

PIEZO2 in somatosensory neurons controls gastrointestinal transit

open access: yesCell, 2023
The gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically breaking down and propelling gut content.
Ardem Patapoutian
exaly   +2 more sources

Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity [PDF]

open access: yesJournal of Personalized Medicine, 2022
As an essential component of mechano-gated ion channels, critically required for mechanotransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin.
Jorge García-Piqueras   +2 more
exaly   +2 more sources

Labeling PIEZO2 activity in the peripheral nervous system

open access: yesNeuron, 2023
Sensory neurons detect mechanical forces from both the environment and internal organs to regulate physiology. PIEZO2 is a mechanosensory ion channel critical for touch, proprioception, and bladder stretch sensation, yet its broad expression in sensory ...
Ardem Patapoutian, Kara L Marshall
exaly   +2 more sources

Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons

open access: yesJournal of Proteome Research, 2016
The ability of somatosensory neurons to perceive mechanical stimuli relies on specialized mechanotransducing proteins and their molecular environment. Only recently has the identity of a major transducer of mechanical forces in vertebrates been revealed ...
Miso Mitkovski   +2 more
exaly   +2 more sources

Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism

open access: yesCell Metabolism
Systemic metabolism ensures energy homeostasis through inter-organ crosstalk regulating thermogenic adipose tissue. Unlike the well-described inductive role of the sympathetic system, the inhibitory signal ensuring energy preservation remains poorly ...
Fabian S Passini, Sharon Krief
exaly   +2 more sources
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