Results 131 to 140 of about 433,754 (318)

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Comprehensive lung microbial gene and genome catalogs assist the mechanism survey of Mesomycoplasma hyopneumoniae strains causing pig lung lesions

iMeta
Understanding the community structure of the lower respiratory tract microbiome is crucial for elucidating its roles in respiratory tract diseases. However, there are few studies about this topic due to the difficulty in obtaining microbial samples from ...
Jingquan Li, Fei Huang, Yunyan Zhou, Tao Huang, Xinkai Tong, Mingpeng Zhang, Jiaqi Chen, Zhou Zhang, Huipeng Du, Zifeng Liu, Meng Zhou, Yiwen Xiahou, Huashui Ai, Congying Chen, Lusheng Huang   +14 more
doaj   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Pig and pigmeat industries: safeguard action against imports [PDF]

On 26 June 1998 the Treasurer referred the question of whether safeguard action is warranted against imports of meat of swine, frozen, falling within tariff sub-heading 0203.29 of the Australian Customs Tariff.
Productivity Commission
core  

Pig health, recording, production and finance A producer's guide [PDF]

, 1988
SIGLEAvailable from British Library Document Supply Centre- DSC:88/22841(Pig) / BLDSC - British Library Document Supply CentreGBUnited ...
Pig Veterinary Society, Malmesbury (United Kingdom)
core  

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Estimated breeding values for number born alive in pigs - do they really work? [PDF]

, 2012
Estimated breeding values (EBVs) have been used in pig genetic improvement programs for several years. Reproductive traits, such as number born alive (NBA), have only low to moderate heritability (et al., 2005).
Suarez, M, Braun, J A, Nakavisut, S, Hermesch, S   +3 more
core  

PAM-flexible SpCas9 variants expand the targeting scope for porcine genome editing and cellular disease modeling

BMC Biotechnology
Background CRISPR-Cas-mediated gene editing has revolutionized life sciences, yet the targeting scope of the widely used SpCas9 is limited by its strict requirement for the NGG protospacer adjacent motif (PAM).
Zhiwei Peng, Wenxin Duan, Yuhang Fan, Qiang Yang, Yu Ye, Yuyun Xing   +5 more
doaj   +1 more source

Epidemiology and Emerging Trends of Zoonotic Viral Diseases of Pigs in India

Viruses
Pigs serve as critical reservoirs and amplifiers for numerous zoonotic viral diseases, presenting substantial public health challenges in India. This study highlights the epidemiology and emerging trends of key zoonotic viruses associated with pigs ...
Swaraj Rajkhowa, Joyshikh Sonowal, Seema Rani Pegu, Rajib Deb, Vivek Kumar Gupta   +4 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source