Results 141 to 150 of about 1,329,317 (278)

Method for modulating pigmentation by targeting bet bromodomain proteins

, 2014
Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQl, are used to reduce pigmentation, promote ...
De La Serna ,Ivana, Trivedi, Archit
core  

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Bionic intelligent responsive barbed microneedles synergistically remodel the microenvironment for the treatment of refractory pigmentation disorders (melasma). [PDF]

Mater Today Bio
Ding H, Zhang E, Wang Y, Guo C, Sun Y, Zhang X, Shu Y, Zhi Y, Wang L, Yu D, Sun Y, Ye C, Wu S, Wang J.   +13 more
europepmc   +1 more source

Processing‐Induced Changes in Bioactive Compounds, Physicochemical, Nutritional, and Sensory Properties of Asian Salted Noodles Fortified With Red Beetroot Flour

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Asian salted noodles (ASN) are popular in East and Southeast Asia and in parts of Europe and the Americas. However, ASN are deficient in certain nutrients (e.g., vitamins, minerals, and dietary fiber) and bioactive compounds.
Gia Ngoc Lam, Fan Zhu
wiley   +1 more source

Genetics of Skin, Hair, and Eye Color in Human Pigmentation Disorders. [PDF]

Ann Hum Genet
Manga P, Loftus S.
europepmc   +1 more source

Beyond Activity: The Unified Framework of the Sabatier Principle to Guide Rational Design of Durable and Active Electrocatalysts

Carbon Energy, EarlyView.
In this review, a unified framework of the Sabatier principle is applied to a diverse range of catalytic and electrocatalytic systems for advanced clean energy technologies, with a particular focus on the oxygen reduction reaction (ORR). This approach will guide the design and development of highly active and stable catalysts for fuel cells ...
Wanying Zhang, Quan Zhou, Xuanxuan Bi, Luo Luo, Yunxiang Cheng, Rongyue Wang, Zhongwei Chen   +6 more
wiley   +1 more source

Protein–Anthocyanin Interactions in Food Systems: A Reaction‐Network Perspective on Equilibria, Kinetics, and Degradation Pathways

ChemFoodChem, EarlyView.
Protein–anthocyanin interactions are reinterpreted beyond binding affinity through a reaction‐network perspective. Distinct protein classes modulate anthocyanin behavior through equilibrium shifts, matrix‐driven protection, self‐assembly, or covalent conjugation.
E. Mariana Martins, Victor de Freitas, Susana Soares, Joana Oliveira   +3 more
wiley   +1 more source

Identification of the Mitf gene mutation causing congenital deafness and pigmentation disorders in porcupines using BSA-Seq. [PDF]

Sci Rep
Li K, Huo C, Long H, Tang K, Zhang S.
europepmc   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source