Results 21 to 30 of about 35,784 (230)

The role of the mast cell in pigmentation disorders

Pigment International, 2021
The mast cell is a critical mediator of the inflammatory response by secreting histamine. While histamine is currently not regarded as a melanogen, recent studies have shown histamine release to induce melanogenesis, melanocyte proliferation and ...
Valdemar Wendelboe Nielsen, Simon Francis Thomsen   +1 more
doaj   +1 more source

Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.

PLoS Genetics, 2020
The genetic origin of human skin pigmentation remains an open question in biology. Several skin disorders and diseases originate from mutations in conserved pigmentation genes, including albinism, vitiligo, and melanoma.
Romain Madelaine, Keri J Ngo, Gemini Skariah, Philippe Mourrain   +3 more
doaj   +1 more source

Schamberg's disease: case report with therapeutic success by using colchicine [PDF]

Anais Brasileiros de Dermatologia, 2017
: Pigmented purpuric dermatoses (PPD) include a spectrum of diseases with different clinical aspects, but with similar histopathological features. Specific clinical findings allow the division of PPD in variants.
Maria Lopes Lamenha Lins Cavalcante, Paula Yoshiko Masuda, Fernanda Freitas de Brito, Ana Cecília Versiani Duarte Pinto, Gabriela Itimura, Adauto José Ferreira Nunes   +5 more
doaj   +2 more sources

Phototherapy as an effective treatment for Majocchi's disease - Case report [PDF]

Anais Brasileiros de Dermatologia, 2015
Pigmented purpuric dermatoses are chronic and relapsing disorders characterized by a symmetrical rash of petechial and pigmentary macules, mainly confined to the lower limbs. Purpura annularis telangiectodes of Majocchi is a
Tapan Kumar Dhali, Monica Chahar, Mohammad Asad Haroon   +2 more
doaj   +1 more source

Hypomelanosis of Ito–Brain Melanin Deposition on Magnetic Resonance Imaging: A Preliminary Hypothesis Based on Two Pediatric Cases [PDF]

Annals of Child Neurology
To investigate brain melanin deposition on magnetic resonance imaging (MRI) in hypomelanosis of Ito (HI) by presenting two clinical cases and reviewing relevant literature.
Roshwanth Arbujin, Sameer Peer, Balachandar Vellingiri, Madhu S. Gaddigoudar, Pawan Kumar Ghanghoriya, Arvinder Wander   +5 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

First record of pigmentation disorder in the Fringe-lipped Bat Trachops cirrhosus (Spix, 1823) (Chiroptera: Phyllostomidae) from southeast Brazil [PDF]

Biodiversity Data Journal, 2019
Piebaldism is a genetic pigmentation disorder, which is caused by absence of melanocytes in parts of the skin and/or hair follicles, with eyes and claws normally pigmented.
Ianna Borloti, Vinícius Pimenta, Albert Ditchfield   +2 more
doaj   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Biology of melanocytes in mammals

Frontiers in Cell and Developmental Biology, 2023
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessing a dendritic morphology. These cells migrate to the epidermis and follicles, contributing to skin and hair pigmentation during ...
Ying-Zhe Cui, Xiao-Yong Man
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source