Results 31 to 40 of about 37,175 (246)

A Double-Blinded Placebo Controlled Therapeutic Trial on Patients with Stable Non-Segmental Vitiligo Using A Specially Formulated Reducing Gel [Pseudo-Catalase] Enhanced by Narrow Band Ultraviolet B Exposure [PDF]

International Journal of Medical Arts
Background: Vitiligo is a skin disorder characterized by the loss of melanocyte cells, leading to depigmentation. Treatment options for Vitiligo encompass topical agents, systemic treatments, phototherapy, and surgical interventions.
Ali Elnawam, Shaker Ezzeddin, Amr Mostafa   +2 more
doaj   +1 more source

Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial

Health Science Reports, 2023
Background and Aims Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin.
Nader Pazyar, Maryam Raeispour, Reza Yaghoobi, Maryam Seyedtabib   +3 more
doaj   +1 more source

Skin Pigmentation Types, Causes and Treatment—A Review

Molecules, 2023
Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted by genetics, UV exposure, and some drugs. Patients’ physical appearance, psychological health, and social functioning are all impacted by a sizable number of skin ...
Amin Mahmood Thawabteh, Alaa Jibreen, Donia Karaman, Alà Thawabteh, Rafik Karaman   +4 more
doaj   +1 more source

Mechanism, Formulation, and Efficacy Evaluation of Natural Products for Skin Pigmentation Treatment

Pharmaceutics
Skin pigmentation typically arises from the excessive secretion and accumulation of melanin, resulting in a darker complexion compared to normal skin. Currently, the local application of chemical drugs is a first-line strategy for pigmentation disorders,
Xueli Peng, Yuning Ma, Chenxin Yan, Xiaocen Wei, Linlin Zhang, Hehe Jiang, Yuxia Ma, Suohui Zhang, Mengzhen Xing, Yunhua Gao   +9 more
doaj   +1 more source

Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.

PLoS Genetics, 2020
The genetic origin of human skin pigmentation remains an open question in biology. Several skin disorders and diseases originate from mutations in conserved pigmentation genes, including albinism, vitiligo, and melanoma.
Romain Madelaine, Keri J Ngo, Gemini Skariah, Philippe Mourrain   +3 more
doaj   +1 more source

The role of the mast cell in pigmentation disorders

Pigment International, 2021
The mast cell is a critical mediator of the inflammatory response by secreting histamine. While histamine is currently not regarded as a melanogen, recent studies have shown histamine release to induce melanogenesis, melanocyte proliferation and ...
Valdemar Wendelboe Nielsen, Simon Francis Thomsen   +1 more
doaj   +1 more source

Schamberg's disease: case report with therapeutic success by using colchicine [PDF]

Anais Brasileiros de Dermatologia, 2017
: Pigmented purpuric dermatoses (PPD) include a spectrum of diseases with different clinical aspects, but with similar histopathological features. Specific clinical findings allow the division of PPD in variants.
Maria Lopes Lamenha Lins Cavalcante, Paula Yoshiko Masuda, Fernanda Freitas de Brito, Ana Cecília Versiani Duarte Pinto, Gabriela Itimura, Adauto José Ferreira Nunes   +5 more
doaj   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Hypomelanosis of Ito–Brain Melanin Deposition on Magnetic Resonance Imaging: A Preliminary Hypothesis Based on Two Pediatric Cases [PDF]

Annals of Child Neurology
To investigate brain melanin deposition on magnetic resonance imaging (MRI) in hypomelanosis of Ito (HI) by presenting two clinical cases and reviewing relevant literature.
Roshwanth Arbujin, Sameer Peer, Balachandar Vellingiri, Madhu S. Gaddigoudar, Pawan Kumar Ghanghoriya, Arvinder Wander   +5 more
doaj   +1 more source