Results 31 to 40 of about 1,329,317 (278)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Schamberg's disease: case report with therapeutic success by using colchicine [PDF]

Anais Brasileiros de Dermatologia, 2017
: Pigmented purpuric dermatoses (PPD) include a spectrum of diseases with different clinical aspects, but with similar histopathological features. Specific clinical findings allow the division of PPD in variants.
Maria Lopes Lamenha Lins Cavalcante, Paula Yoshiko Masuda, Fernanda Freitas de Brito, Ana Cecília Versiani Duarte Pinto, Gabriela Itimura, Adauto José Ferreira Nunes   +5 more
doaj   +2 more sources

Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity [PDF]

, 2013
The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would ...
Salomone, Joseph R., Joseph R Salomone, Williams, Thomas M., William A. Rogers (451944), Camino, Eric M., Davis, Kristen A., Kristen A Davis, Joseph R. Salomone (451945), Rebeiz, M, Eric M. Camino (451947), David J Tacy, Williams, TM, Davis, KA, Mark Rebeiz (451949), Thomas M. Williams (10343), Rogers, William A., Tacy, David J., Rebeiz, Mark, Rogers, WA, Eric M Camino, Camino, EM, Levine, Michael, Kristen A. Davis (451948), Tacy, DJ, David J. Tacy (451946), Salomone, JR, William A Rogers, Mark Rebeiz, Thomas M Williams   +28 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aberrant Pigmentation in a Schooling Cownose Ray (Rhinoptera bonasus) in Chesapeake Bay, Virginia, USA

Ecology and Evolution
While pigmentation disorders such as albinism have been documented in a range of elasmobranch species, including the American cownose ray (Rhinoptera bonasus), the implications of these rare conditions for behavior, social dynamics, and fitness remain ...
Morgan F. Bennett‐Smith, Taylor Griffith, Helena Janulis, Eloise B. Richardson, Stephen J. Tomasetti   +4 more
doaj   +1 more source

Hypomelanosis of Ito–Brain Melanin Deposition on Magnetic Resonance Imaging: A Preliminary Hypothesis Based on Two Pediatric Cases [PDF]

Annals of Child Neurology
To investigate brain melanin deposition on magnetic resonance imaging (MRI) in hypomelanosis of Ito (HI) by presenting two clinical cases and reviewing relevant literature.
Roshwanth Arbujin, Sameer Peer, Balachandar Vellingiri, Madhu S. Gaddigoudar, Pawan Kumar Ghanghoriya, Arvinder Wander   +5 more
doaj   +1 more source

Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging

, 2021
Skin disorders showing abnormal pigmentation are often difficult to manage because of their uncertain etiology or pathogenesis. Abnormal pigmentation is a common symptom accompanying aging skin.
Ai-Young Lee
core   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing [PDF]

, 2013
Includes abstract.Includes bibliographical references.On healing, partial-thickness burn wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes.
Chang, Ju-Wei
core   +1 more source

Development of Pigmentation-Regulating Agents by Drug Repositioning

, 2021
Skin color is determined by the processes of melanin synthesis and distribution. Problems in various molecules or signaling pathways involved in melanin synthesis contribute to skin pigmentation defects.
Tae-Jin Yoon, Seo-Mi-Gon Jeong
core   +1 more source