The Genetics and Evolution of Human Pigmentation
BiologyHuman skin pigmentation is one of the most visible and variable traits among populations and has been shaped primarily by natural selection in response to ultraviolet (UV) radiation.
Dorra Guermazi, Elie Saliba
doaj +2 more sources
Shining Light on Autophagy in Skin Pigmentation and Pigmentary Disorders
, 2022 Autophagy is a vital process for cell survival and it preserves homeostasis by recycling or disassembling unnecessary or dysfunctional cellular constituents.
Mauro Picardo +7 more
core +1 more source
Development of Pigmentation-Regulating Agents by Drug Repositioning
, 2021 Skin color is determined by the processes of melanin synthesis and distribution. Problems in various molecules or signaling pathways involved in melanin synthesis contribute to skin pigmentation defects.
Tae-Jin Yoon, Seo-Mi-Gon Jeong
core +1 more source
Medicina, 2019 The term congenital hypopigmentary disorders refers to a wide group of heterogeneous hereditary diseases, clinically characterized by inborn pigmentary defects of the iris, hair, and/or skin.
Laura Cristina Gironi +10 more
doaj +1 more source
A Double-Blinded Placebo Controlled Therapeutic Trial on Patients with Stable Non-Segmental Vitiligo Using A Specially Formulated Reducing Gel [Pseudo-Catalase] Enhanced by Narrow Band Ultraviolet B Exposure [PDF]
International Journal of Medical ArtsBackground: Vitiligo is a skin disorder characterized by the loss of melanocyte cells, leading to depigmentation. Treatment options for Vitiligo encompass topical agents, systemic treatments, phototherapy, and surgical interventions.
Ali Elnawam +2 more
doaj +1 more source
mTORC1 activity negatively regulates human hair follicle growth and pigmentation
, 2023 Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a rare neurodevelopmental multisystemic disease characterized by benign ...
Chéret, Jérémy +10 more
core +4 more sources
Evaluating the Effect of K5® Lipogel on the Treatment of Melasma: A Before-After Clinical Trial [PDF]
Disease and DiagnosisBackground: Melasma is a dermatologic condition that has a major effect on self-esteem. Many treatment modalities have been used, mostly with limited success.
Farhad Handjani +3 more
doaj +1 more source
Disorders of pigmentation: unapproved treatments
Clinics in Dermatology, 2002 Aprescription is considered unapproved when the condition being treated is not listed on the package insert or in the Physician’s Desk Reference as an indication for the drug being used. There is a perception among some that if a therapy were truly effective and safe for a particular indication, it would have received official Food and Drug ...
Katsambas, A, Stefanaki, C
openaire +3 more sources
Macroscopic and dermoscopic evaluation used to differentiate subungual haemorrhage from melanocytic lesions [PDF]
Journal of Primary Health Care, 2020 INTRODUCTIONSubungual haemorrhage describes blood located between the nail matrix and nail plate caused by trauma. Lack of recalled trauma and long duration of nail pigmentation results in specialist referrals to rule out malignant pathology.
Amanda Oakley, Mirain Phillips
doaj
Inherited Reticulate Pigmentary Disorders
, 2023 Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin conditions characterized by hyperpigmented and/or hypopigmented macules.
Hsin-Su Yu +5 more
core +1 more source