Results 251 to 260 of about 77,471 (339)

From Somatic Driver to Molecular Therapy in Retinal, Choroidal and Periocular Vascular Disease: Mosaicism, Targetable Pathways and Ocular Toxicity. [PDF]

Int J Mol Sci
Adamski W.
europepmc   +1 more source

Caring for Rare Genetic Disease: A Vision for the Future

Journal of Genetic Counseling, Volume 35, Issue 5, October 2026.
ABSTRACT The United Nations, 2021 resolution to promote and protect the human rights of the estimated 300 million People Living with a Rare Disease and their families, set a milestone worldwide. At the same time, the successful diagnostic results of large genomic initiatives are reshaping rare disease healthcare in many countries.
Ruth Horn, Sarah L. Wynn, Sofia Douzgou Houge   +2 more
wiley   +1 more source

Copanlisib in combination with nivolumab formicrosatellite stable colorectal cancer: a phase 1/2 trial. [PDF]

Nat Commun
Christenson ES, Wala JA, Parkinson R, Collins NB, Jakubowski C, Lin JR, Qian K, Lu J, Wang H, Ho WJ, Chan S, Kulikowicz E, Klein R, Cetasaan Y, Johnson E, Berg M, Meyerhardt JA, Le DT, Schlechter BL, Browner I, Zheng L, Singh H, Donehower R, Jaffee EM, Sorger PK, Giannakis M, Azad N.   +26 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.E545Q [PDF]

, 2020
openaire   +1 more source

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1209-1225, October 2026.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source

Application of Systems Genetics to Investigate Molecular Pathology of Early-Onset Colorectal Cancer. [PDF]

Chem Biol Drug Des
Kim MJ, Carr SL, Kulkarni V, Manchadi ML.   +3 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.E542K [PDF]

, 2020
openaire   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Exploratory Analysis of PTEN Deficiency by Immunohistochemistry from the Phase III CAPItello-291 Trial. [PDF]

Clin Cancer Res
Jhaveri K, Rugo HS, Cortés J, Oliveira M, Howell SJ, Dalenc F, Gomez HL, Hu X, Krivorotko P, Loibl S, Okera M, Park YH, Sohn J, Toi M, Tokunaga E, Zhukova L, Nardone A, Wadsworth I, D'Cruz C, Wantenaar T, Das D, de Bruin EC, Turner NC.   +22 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.E545G [PDF]

, 2020
openaire   +1 more source