Results 241 to 250 of about 77,471 (339)

Association of HRD Score With Efficacy of Neoadjuvant Short‐Course Radiotherapy Plus Sequential Chemoimmunotherapy in pMMR Locally Advanced Rectal Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Homologous recombination deficiency (HRD) has been reported to be associated with increased sensitivity to platinum‐based treatment and radiotherapy in some solid tumors. Aim This study investigated the correlation between HRD score and treatment response to neoadjuvant short‐course radiotherapy combined with sequential chemotherapy
Xin Ran, He Xiao, Peng Zhou, Juan He, Mengyuan Si, Xiuqiong Chen, Xiaona Su, Zhuo Chen, Jia Du, Xiaoyan Dai, Xiao Yang, Haode Shen, Zongsheng He, Fan Li, Mengxia Li, Chuan Chen   +15 more
wiley   +1 more source

Emerging Strategies Targeting the PI3K/AKT/mTOR Pathway in HR+/HER2- Advanced Breast Cancer. [PDF]

Drugs
Lei L, Canning M, Sakach E, Lateef A, Kamga L, Abid M, Kalinsky K, Gandhi S.   +7 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.E545K [PDF]

, 2020
openaire   +1 more source

Trigonelline Alleviates Neuroinflammation in AAV‐SynA53T Parkinson's Disease Model Mice: Involvement of PI3K/AKT–NF‐κB Signaling and Gut Microbial‐Metabolic Remodeling

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Trigonelline alleviated motor deficits, α‐synuclein‐associated pathology, and neuroinflammatory changes in AAV‐SynA53T mice. These effects were accompanied by reduced PI3K/AKT–NF‐κB signaling activity, improved intestinal barrier‐associated features, and gut microbiota–metabolome remodeling.
Mozi Chen, Yiyao Dong, Jie Zheng, Yan Lin, Qiyao Li, Chuhua Wei, Linpei Zhuo, Yan He, Jing Sun, Feng Fu, Jiaming Liu   +10 more
wiley   +1 more source

Case Report: Concomitant BRAF V600E and PIK3CA H1047R mutations in a micro-papillary thyroid carcinoma with extensive nodal metastasis. [PDF]

Front Oncol
Zhong L, Huang Z, Song X, Li Y, Wu D.
europepmc   +1 more source

Ginsenoside Rb1 From the Functional Food Panax ginseng Suppresses Pancreatic Cancer Progression via Macrophage Reprogramming Through the PI3K‐AKT Pathway

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Food‐derived bioactive compound ginsenoside Rb1 (GRB1) inhibits pancreatic cancer progression by reprogramming tumor‐associated macrophages. GRB1 suppresses the PI3K–AKT signaling pathway, thereby blocking M0‐to‐M2 macrophage polarization and reducing the accumulation of immunosuppressive macrophages within the tumor microenvironment.
Chang‐Sheng Dong, Gaoqiang Wang, Ying Niu, Xiuqiao Sun, Wenyi Ren, Jiliang Zhang, Yi Zhang, Rui‐Xin Wu, Xiaoxiong Wu   +8 more
wiley   +1 more source

Adjuvant aspirin for colorectal cancer with PIK3CA-mutated and COX-2 overexpressed tumours: the ASCOLT translational research study and meta-analysis. [PDF]

EBioMedicine
Segelov E, Li S, Li I, Mouradov D, Yip S, Day D, Jeffery M, Zielinski R, Nott L, Sun Y, Christie M, Ho GF, Chao TY, Rahman N, Foo E, Chia J, Gebski V, Toh HC, Sieber OM, Simes J.   +19 more
europepmc   +1 more source

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation. [PDF]

Signal Transduct Target Ther
Shi Q, Liu J, Chu Q, Zeng Y, Zhang Y, Jiang S, Yuan X, Zhu D, Li L.   +8 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.E545A [PDF]

, 2020
openaire   +1 more source

A Serum lncRNA Signature Determines Oncogenic YAP Activity in Cancer Patients

International Journal of Cancer, Volume 159, Issue 7, Page 1829-1843, 1 October 2026.
Long non‐coding RNAs (lncRNAs) signatures are promising cancer biomarkers, since their dysregulation in tumors is reflected in body fluids. In this study, next‐generation sequencing, bioinformatics, and gene expression data were combined to investigate an lncRNA signature linked specifically to the cancer‐promoting YAP in several cancer types ...
Fabian Rose, Nada El‐Ekiaby, Lilija Wehling, Sofia Maria Elisabeth Weiler, Jennifer Schmitt, Marcell Tóth, Fabiola Pedrini, Amruta Damle‐Vartak, Carsten Sticht, Rossella Pellegrino, Injie Omar Fawzy, Merna Hatem Mohamed Hamad, Mohamed Negm, Dina Omar, Hossam Eldeen Soliman, Gamal Esmat, Thomas Longerich, Thomas Illig, Bruno Christian Köhler, Anna Saborowski, Heike Bantel, Arndt Vogel, Peter Schirmacher, Ahmed Ihab Abdelaziz, Kai Breuhahn   +24 more
wiley   +1 more source