Results 221 to 230 of about 77,471 (339)

PIK3CA NP_006209.2:p.E542V [PDF]

, 2020
openaire   +1 more source

Optimizing the ER Cutoff in HER2‐Positive Breast Cancer: ER ≥ 50% Predicts Low pCR Rates and Resistance to Antibody‐Drug Conjugates in the Neoadjuvant Setting

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Estrogen receptor (ER)‐positive/HER2‐positive breast cancer demonstrates significantly lower rates of pathological complete response (pCR) to neoadjuvant HER2‐targeted therapies compared to ER‐negative/HER2‐positive disease. However, the optimal ER positivity cutoff for clinically meaningful patient stratification remains undefined.
Tian Du, Min Lin, Gehao Liang, Yan Wang, Hao Wu, Zixuan Zhao, Luhao Sun, Jun Tang   +7 more
wiley   +1 more source

<i>Ligusticum sinense</i> Oliv. cv. Chaxiong Extract Alleviates Nitroglycerin-Induced Migraine-like Responses in Rats: Associations with Glycerophospholipid Metabolism and PI3K/AKT Signaling. [PDF]

Int J Mol Sci
Zhu Y, Dong Y, Jiang S, Qin Q, He Y, Wu D, Zhang S, Wei J.   +7 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.H1047Y [PDF]

, 2020
openaire   +1 more source

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy, Annette Sereika, Karen Kaul, Megan Parilla, Mir B. Alikhan, Michael Bouma, Dyson Wake, Peter J. Hulick, Henry M. Dunnenberger, Linda M. Sabatini, Mathew Yang, Kathy A. Mangold, Erin Proctor, Nicholas Evans, Nicholas Miller, Donald L. Helseth Jr, Darryck Maurer, Justin Brueck, Janardan Khandekar, Bruce Brockstein   +19 more
wiley   +1 more source

Anti‐Inflammatory Effects of Vicatia thibetica De Boiss. in Rheumatoid Arthritis and Associated Multi‐Pathway Modulation In Vivo

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Vicatia thibetica de Boiss. (VTDB) extracts and fractions were screened for anti‐rheumatoid arthritis activity via UHPLC‐MS, network pharmacology, and CIA rat models. VTDB‐nBuOH stood out, regulating PI3K/Akt, JAK2/STAT3, macrophage polarization, and gut microbiota to relieve joint inflammation, with proteomics verifying its multi‐pathway regulatory ...
Mo‐Zi‐Li Adu, Wei Jiang, Min Li, Bo‐Wei Xia, En Yuan, Yue‐Zhi Tan, Wu‐Xin Yang, Guo‐Yue Zhong, Qin‐Ge Ma, Rong‐Rui Wei   +9 more
wiley   +1 more source

PIK3CA Gene Amplification [PDF]

, 2020
openaire   +1 more source

Integrated Phytochemical, Immunological, and Network Pharmacology Investigation of Anti‐Inflammatory Lignans From Zanthoxylum armatum Fruits

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Bioassay‐guided fractionation of Zanthoxylum armatum fruits identifies three bioactive lignans—sesamin, fargesin, and eudesmin. The identified lignans attenuate CpG‐induced dendritic‐cell activation by reducing IL‐12 expression and CD80. Network pharmacology and molecular docking suggest involvement of multiple inflammatory signalling pathways ...
Ningthoujam Indrajit Singh, Salam Pradeep Singh, Chayan Mukherjee, Chingakham Brajakishor Singh   +3 more
wiley   +1 more source

PIK3CA wt Allele [PDF]

, 2020
openaire   +1 more source

Systems Pharmacology and Multitarget Modulation of Letrozole–HFD‐Induced Polycystic Ovarian Syndrome by Fruit Pulp of Prunus armeniaca

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Integrated systems pharmacology and in vivo evaluation reveal that hydroalcoholic extract of fruit pulp of Prunus armeniaca (HAE of FPPA) ameliorates letrozole–HFD‐induced PCOS through multitarget modulation. Network analysis identifies 105 shared targets enriched in PI3K/Akt, MAPK, HIF‐1, and inflammatory pathways, while treatment improves hormonal ...
Ratna Priya, Nitish Singh Jangwan, Swati Dobhal, Shradha Bisht, Mamta F. Singh   +4 more
wiley   +1 more source