Results 201 to 210 of about 77,471 (339)

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability. [PDF]

Cancers (Basel)
Ottaiano A, Picone C, Santorsola M, Berretta M, Cutolo C, Belli A, Izzo F, Di Carluccio N, Acampora A, Tarotto L, Stilo S, Correra M, Capuozzo M, Carratù AC, Caraglia M, Nasti G, Savarese G.   +16 more
europepmc   +1 more source

Prostatic Adenosquamous Carcinoma With a Minute Squamous Component in the Initial Biopsy and Early Liver Metastasis: A Case Report

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction We report a case of de novo prostatic adenosquamous carcinoma with a minute squamous component in the initial biopsy and early liver metastasis despite a marked prostate‐specific antigen response. Case Presentation A 72‐year‐old man was diagnosed with locally advanced prostate cancer with nodal and multiple bone metastases ...
Yohei Tsubouchi, Taku Naiki, Aya Naiki‐Ito, Rei Unno, Toshiki Etani, Takashi Nagai, Toshiharu Morikawa, Daiki Ishikawa, Hiroko Suzuki, Takahiro Yasui   +9 more
wiley   +1 more source

PIK3CA silencing restores anoikis sensitivity in endothelial cells. [PDF]

Mol Biol Rep
Pereira DMC, de Sousa Mesquita AP, da Silva Cruz A, Donatti L, Nader HB, Lopes CC.   +5 more
europepmc   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

PIK3CA in the transformation of EGFR‑mutant lung adenocarcinoma to small cell lung cancer following acquired targeted therapy resistance. [PDF]

Chin Med J (Engl)
Xu J, Zhang W, Wang C, Zhang M, Chen M, Lin P, Chen Y, Deng C, Yu Z.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in PIK3CA mutant breast cancer. [PDF]

J Biol Chem
Lero MW, Morgan JS, Card MA, Zhu LJ, Li J, Li R, Bui QT, Mohlmann E, Goel HL, Shaw LM.   +9 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Functional Characterization of Putative Novel MicroRNA-1133 in the Antioxidant Effects of Metformin in Hyperglycemia-Induced Endothelial Cells. [PDF]

Int J Mol Sci
Othman NS, Aminuddin A, Hamid AA, Abidin SZ, Syafruddin SE, Ahmad MF, Jaffar FHF, Othman Basri NA, Ugusman A.   +8 more
europepmc   +1 more source

PIK3CA NP_006209.2:p.H1047T [PDF]

, 2020
openaire   +1 more source