Results 181 to 190 of about 77,471 (339)
Cell Proliferation, EarlyView.DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo +10 more
wiley +1 more source
Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source
Nutrition & MetabolismBackground Deficiency of insulin signaling components may act as the underlying mechanisms for insulin resistance and type 2 diabetes (T2D). N6-methyladenosine (m6A) is emerging as an important regulatory mechanism in gene expression at the post ...
Jing Dong +6 more
doaj +1 more source
Pericerebral spaces as diagnostic signposts in fetal central nervous system pathologies
Ultrasound in Obstetrics &Gynecology, EarlyView.
L. Guibaud, S. Cabet
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Genetic testing in paediatric neurological disorders
Developmental Medicine &Child Neurology, EarlyView.In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba +15 more
wiley +1 more source
Immunology, EarlyView.Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang +7 more
wiley +1 more source
Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases
Journal of Periodontal Research, EarlyView.This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi +10 more
wiley +1 more source
Investigation of Oncogenic Gene Mutation and Associated Protein Expression in Ameloblastic Carcinoma
Oral Diseases, EarlyView.ABSTRACT Objective This study aimed to investigate gene mutations in ameloblastic carcinoma (AC) including BRAF, KRAS, and PIK3CA, along with associated protein expressions of BRAF V600E, p‐ERK1/2, and p‐mTOR, which represent activation of MAPK/ERK and PI3K/mTOR pathways, respectively.
Puangwan Lapthanasupkul +4 more
wiley +1 more source
Clinical Characterization of Skin Findings on the Hands in Proteus Syndrome
Pediatric Dermatology, EarlyView.ABSTRACT Background Proteus syndrome is a progressive asymmetric overgrowth disorder caused by mosaic activating variants in AKT1. It most frequently affects the skin, soft tissues, bones, and central nervous system and increases the risk for certain tumors and venous thromboembolism. A hallmark feature is the progressive plantar cerebriform connective
Samantha D. Verling +4 more
wiley +1 more source