Results 161 to 170 of about 77,471 (339)
Frequent PIK3CA-activating mutations in hidradenoma papilliferums
, 2017 Hidradenoma papilliferum (HP) is a benign epithelial tumor most commonly seen in the vulva. It is proposed to be derived from the anogenital mammary-like glands and is histologically very similar to the mammary intraductal papilloma (IP).
郭冠廷;蔡佳惠;朱家瑜;廖肇裕;洪楨邦;沈宜萱 +1 more
core +1 more source
Orbital Lymphatic Malformations Are Associated With Intracranial Vascular Anomalies
The Laryngoscope, EarlyView.In this retrospective series, all seven patients with orbital lymphatic malformations had intracranial vascular anomalies consistent with cerebrofacial venous metameric syndrome and hotspot PIK3CA variants identified through tissue‐based sequencing. Five patients treated with alpelisib experienced symptom improvement within 6 months.
Kelsey A. Loy +11 more
wiley +1 more source
PIK3CA amplifications in human lung carcinomas
, 2011 Ein Tumorgewebe-Array mit über 600 humanen Lungenkarzinomen wurde mittels Fluoreszenz-in-situ-Hybridisierung auf die Kopiezahl des Gens PIK3CA untersucht und die Ergebnisse mit klinischen und pathologischen Daten verglichen. Besonders häufig zeigten sich
Schacht, Hannes
core
Example of PIK3CA (3q26.3) copy number gain detected by FISH.
, 2018 (A) normal copy number at the PIK3CA locus in normal penile epithelium (B) normal copy number of the PIK3CA locus in PeIN (C) copy gain of the PIK3CA locus in primary PSCC. PIK3CA locus—designated by the red probe & Control—designated by the green probe.
Anthony Adimonye (5394899) +9 more
core +1 more source
Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma
The Laryngoscope, EarlyView.We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano +3 more
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C‐cells and accounts for 1–5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis.
Anna Citarella +24 more
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Fibroblast growth factor receptor 1 (FGFR1) amplification, a significant cancer alteration with both prognostic and therapeutic relevance, lacks a standardized definition. The relationship between FGFR1 copy number (CN) variations and tumour microenvironment (TME) characteristics also remains poorly understood.
Yike Gao +6 more
wiley +1 more source
An investigation of PIK3CA mutations in isolated macrodactyly
, 2018 Somatic PIK3CA mutations may relate to pathogenesis of isolated macrodactyly. We set up to test the association between PIK3CA mutations with isolated macrodactyly in order to establish a more accurate and molecular mechanism-based diagnosis and ...
Douglas T. Hutchinson +5 more
core +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.There is limited understanding of the impact of underlying RAS/RAF mutational status on total neoadjuvant therapy metastatic tumor response rates in curative Stage IV rectal cancer patients. Complete metastatic tumor response to TNT was demonstrated in half as many mRAS as wtRAS patients and disease progression was higher in patients harboring RAS ...
Tracy R. Fitzsimmons +8 more
wiley +1 more source
Molecular OncologyPhosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha [PIK3CA, encoding PI3Kalpha (also known as p110α)] is one of the most commonly aberrated genes in human cancers.
Shibo Zhang +6 more
doaj +1 more source