Results 281 to 290 of about 77,471 (339)

Tissue Factor‐High Ovarian Clear Cell Carcinoma Shows Immune‐Cold Features and Preclinical Activity of Tisotumab Vedotin

Cancer Science, Volume 117, Issue 10, Page 2838-2851, October 2026.
F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Yutaro Mori, Ryo Tamura, Kotaro Takahashi, Kaoru Yamawaki, Tatsuya Ishiguro, Teiichi Motoyama, Koji Okamoto, Kosuke Yoshihara   +7 more
wiley   +1 more source

Alpelisib enhances cisplatin mediated cytotoxicity in non-mutated, PIK3CA-dependent high-grade serous ovarian cancer. [PDF]

J Ovarian Res
Mehrotra M, Chakraborty S, Saldanha E, Joshi D, Dhadve A, Sakpal A, Chandrani P, Maheshwari A, Menon S, Ghosh J, Gupta S, Ray P.   +11 more
europepmc   +1 more source

Clinical Efficacy and Mechanisms of ZiyuShuang, an Anti‐Skin Aging Formula Identified Through Network Medicine Framework Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin aging, a key aspect of physiological decline, markedly affects appearance, making strategies to delay it vital for quality of life. Materials and Methods We applied network medicine analysis to screen herbal medicines from the TCMSP database, yielding an anti‐skin aging formula, ZiYuShuang (ZYS).
Yingpeng Tong, Xiangmei Ni, Xinnan Jiang, Ru Zhang, Pengcheng Guo, Chunbo Feng, Jianxin Wang   +6 more
wiley   +1 more source

Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT The differentiation between benign and malignant biliary strictures remains a significant clinical challenge. Recent studies have suggested that next generation sequencing (NGS) can improve the diagnostic accuracy. However, evidence on its performance in routine clinical practice is limited. Therefore, validation of the diagnostic value of NGS
Antonia Gillmeister, Julia Husman, Renate Schmelz, Stefan Brückner, Jochen Hampe, Daniela Aust, Sebastian Zeissig   +6 more
wiley   +1 more source

Mechanisms of acquired resistance to osimertinib in EGFR T790M-Positive lung adenocarcinoma. [PDF]

Front Genet
Cui K, Zhu R, Li J.
europepmc   +1 more source

Pleural Mesothelioma With Unusual Squamous Differentiation: A Clinicopathological Case Report With Molecular Insights From Whole‐Exome Sequencing

Pathology International, Volume 76, Issue 10, October 2026.
This case report highlights a rare histological variant of pleural mesothelioma with partially squamous differentiation in an 81‐year‐old man with occupational asbestos exposure. In addition to histological, immunohistochemical and fluorescence in situ hybridization analyses, indicating a common mesothelial origin of both tumor components, whole‐exome ...
Julius Bodemeyer, Mara Elisa Mierzwa, Jörg Seraphin, Rizkallah Maroun, Wolfgang Körber, Christoph Engelke, Felix Bremmer, Tessa Rosenthal, Tim Heißenberg, Kirsten Reuter‐Jessen, Philipp Ströbel, Alexander Marx, Hanibal Bohnenberger   +12 more
wiley   +1 more source

Clinically actionable genomic alterations in breast cancer brain metastases. [PDF]

ESMO Open
Griguolo G, Collesei A, Lazzarini E, Bottosso M, Dieci MV, Fineberg S, Bauchet L, Landa G, Miglietta F, Jacob J, Rigau V, La Commare M, Trovò L, Fassan M, Jacot W, Dei Tos AP, Indraccolo S, Darlix A, Guarneri V.   +18 more
europepmc   +1 more source

The evolving role of immunotherapy in ovarian cancer

Cancer, Volume 132, Issue 18, 15 September 2026.
Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani, Laura Venegas, Amit M. Oza   +2 more
wiley   +1 more source

Genomic and epigenomic diversity of breast cancer across Western and MENA populations: implications for precision oncology. [PDF]

Front Oncol
Shaikh S, Akbar A, Khalifey HT, Raziq T, Abu-Saleh D, Alruwaili H, Almansouri S, Arora I, Aroke E, Freij KW, Khan MI, Yaqinuddin A.   +11 more
europepmc   +1 more source

Clinicopathological characterization of cervical squamous cell carcinoma with <i>PIK3CA</i> hotspot mutation: A single-institution study. [PDF]

Oncol Lett
Murray J, Kaur H, Smith C, Wu AA, Wu LS, Tsai YC, Hung CF, Wu TC, Xing D.   +8 more
europepmc   +1 more source