Results 291 to 300 of about 77,471 (339)

Chemical Characterization and Mechanism Analysis of Ganjianglingzhu Decoction in the Treatment of Low Back Pain Based on UPLC-Q-TOF-MS/MS and Network Pharmacology. [PDF]

Rapid Commun Mass Spectrom
Chen B, Li P, Shi J, Xu F, Sun S.
europepmc   +1 more source

Downregulation of miR203 Induces Overexpression of <i>PIK3CA</i> and Predicts Poor Prognosis of Gastric Cancer Patients [Retraction]. [PDF]

Drug Des Devel Ther
europepmc   +1 more source

Cost-effectiveness of inavolisib-based therapy in PIK3CA-mutated advanced breast cancer in the USA. [PDF]

Breast
Liu S, Wang K, Chen H, Wan Z, Dou L, Li S.   +5 more
europepmc   +1 more source

<i>ESR1</i> and <i>PIK3CA</i> circulating tumor DNA (ctDNA) mutation status as predictive biomarkers beyond variant allele fraction (VAF) in metastatic breast cancer. [PDF]

J Liq Biopsy
Fusco N, Malapelle U.
europepmc   +1 more source

Impact of somatic PIK3CA mutations on clinical outcomes in HER2-positive breast cancer. [PDF]

Breast Cancer Res
Stabellini N, de Oliveira SD, Mizukami T, Sweeney SM, Schultz N, Kehl K, Riely G, Panageas K, Schrag D, Bedard P, Micheel C, Guo X, Montero AJ.   +12 more
europepmc   +1 more source

CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas. [PDF]

Cancer Chemother Pharmacol
Balaguer-Lluna L, Resa-Parés C, Brstilo L, Gómez-Caballero A, Baulenas-Farrés M, Mohr J, Hu Y, Aschero R, Rodríguez A, Botteri G, Rodríguez E, Li-Chen L, Mañogil R, Marino F, Martínez-Velasco N, Ruano A, García-Pelayo Á, Giron A, Mora J, Lavarino C, Sánchez-Navarro M, Teixidó M, Ormazabal A, Artuch R, Unceta N, Schaiquevich P, Carcaboso AM.   +26 more
europepmc   +1 more source

Gene of the month: PIK3CA

Journal of Clinical Pathology, 2015
PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis.
Lai, Ken (R17310), Killingsworth, Murray C. (R14279), Lee, Cheok Soon (R13259)   +2 more
openaire   +4 more sources

Somatic mosaicism of PIK3CA mutation in PIK3CA-related overgrowth disorders

, 2014
Background and aims Somatic mosaicism of phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA) mutation, one of the genes involved in the PI3K/AKT/mTOR pathway, is associated with a group of rare asymmetrical overgrowth syndrome that is collectively named as PIK3CA-related overgrowth disorder.
Kuong, EYL, Choi, KY, Wong, WL, Li, RCH, To, M, Chow, W, Leung, KC, Yeung, KS, Chan, GCF, Chung, BHY   +9 more
openaire   +2 more sources

Alpelisib for treatment of patients with PIK3CA-related overgrowth spectrum (PROS)

Genetics in Medicine, 2023
PURPOSE PROS encompasses several rare conditions resulting from activating variants in PIK3CA. Alpelisib, a PI3Kα-selective inhibitor, targets the underlying etiology of PROS, offering a novel therapeutic approach to current management strategies.
Stuart Turner
exaly   +2 more sources