Results 51 to 60 of about 297,742 (253)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mechanism of double pile accumulation affecting fermentation of sauce-flavor Baijiu [PDF]

Zhongguo niangzao
In the process of the sixth rounds of high temperature accumulation of sauce-flavor (Jiangxiangxing) Baijiu, the large pile and double pile stacking fermentation of the two groups of piles was carried out, and the effect of increasing specific surface ...
MOU Zhen, WANG Ding, WANG Yabin, QIU Yong, LUO Aimin
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Investigation of Accidents during Storage Caused by Fermentation or Oxidation from SSSR and Fishmeal Using Thermal Analysis and Frank-Kamenetskii Theory

Recycling, 2018
In Japan, where soy sauce production and the fishery industries thrive, soy sauce squeezing residue (SSSR) and fishmeal, which are operational byproducts of these sectors, are produced as waste materials for recycling.
Naoharu Murasawa, Hiroshi Koseki, Yusaku Iwata, Takabumi Sakamoto   +3 more
doaj   +1 more source

Effects of different microbial agents on bedding treatment of ectopic fermentation of buffalo manure

Frontiers in Microbiology, 2022
IntroductionThe rapid development of the farming industry has increased the amount of manure produced by livestock and poultry, causing increasingly prominent environmental pollution problems.
Kaifeng Niu, Kaifeng Niu, Chen Chao, Chen Chao, Xinxin Zhang, Xinxin Zhang, Zhigao An, Zhigao An, Jiayan Zhou, Jiayan Zhou, Liguo Yang, Liguo Yang, Liguo Yang   +12 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Screening of dominant microbial communities and their regulatory mechanisms on tea quality transformation during pile-fermentation of Tianjian dark tea

International Journal of Food Properties
The final quality of Tianjian dark tea strongly depends on pile-fermentation and aging. However, poorly understood microbial mechanisms have led to inconsistent quality and lengthy cycles during traditional production.
Jiang Xie
doaj   +1 more source

Development of LRFD Procedures for Bridge Pile Foundations in Iowa Final Report, June 2010 [PDF]

, 2010
For well over 100 years, the Working Stress Design (WSD) approach has been the traditional basis for geotechnical design with regard to settlements or failure conditions.

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