Results 71 to 80 of about 542,971 (347)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Invited review: Effect of temperature on a granular pile

, 2010
As a fragile construction, a granular pile is very sensitive to minute external perturbations. In particular, it is now well established that a granular assembly is sensitive to variations of temperature.
de Gennes, Janssen, Makse, Thibaut Divoux   +3 more
core   +2 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Fluorescence decay data analysis correcting for detector pulse pile-up at very high count rates

, 2017
Using Time-Correlated Single Photon Counting (TCSPC) for the purpose of fluorescence lifetime measurements is usually limited in speed due to pile-up.
Dowler, Rhys, Koenig, Marcelle, Patting, Matthias, Reisch, Paja, Sackrow, Marcus, Wahl, Michael   +5 more
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Isostaticity in two dimensional pile of rigid disks

, 2003
We study the static structure of piles made of polydisperse disks in the rigid limit with and without friction using molecular dynamic simulations for various elasticities of the disks and pile preparation procedures.
Ball R. C., Ball R. C., Moukarzel C. F., Moukarzel C. F., Silbert L. E., Tkachenko A. V.   +5 more
core   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Internal dynamics of the galaxy cluster Abell 545

, 2011
Diffuse radio emission in galaxy clusters, and their connection with cluster mergers, are still debated. We seek to explore the internal dynamics of the radio halo cluster Abell 545.
Abell, Anders, Ashman, Bacchi, Bardelli, Barrena, Barrena, Barrena, Beers, Beers, Beers, Beers, Beers, Bekki, Bell, Bertin, Binggelli, Bird, Biviano, Bonafede, Boschin, Boschin, Boschin, Boschin, Brunetti, Bullock, Buote, Buote, Böhringer, Carlberg, Cassano, Cassano, Cassano, Cassano, Cassano, Cavaliere, Chilingarian, Chilingarian, D. Eckert, Danese, David, den Hartog, Dolag, Dolag, Donnert, Dressler, Dubinsky, Ellingson, Ensslin, Ensslin, Ensslin, Fadda, Fasano, Ferrari, Ferrari, Ferrari, Finoguenov, Fukugita, Giovannini, Giovannini, Girardi, Girardi, Girardi, Girardi, Girardi, Girardi, Goto, Govoni, Hashimoto, Henriksen, Henry, Hoeft, Kalberla, Kennicutt, Kneib, Landolt, Leccardi, Leccardi, Limber, Lin, Liu, Loeb, M. Girardi, M. Rossetti, Malumuth, Markevitch, Markevitch, Mastropietro, Menci, Merritt, Million, Mushotzky, Navarro, Niederste-Ostholt, Nieto, Okabe, Owers, Pinkney, Pisani, Pisani, Quintana, R. Barrena, Ramella, Ramella, Ricker, Rines, Roettiger, Roettiger, Roettiger, Rossetti, Rudick, S. De Grandi, Salinas, Salinas, Sarazin, Sastry, Schlegel, Schneider, Springel, Struble, Struble, The, Tonry, Tribble, van Dokkum, W. Boschin, Wainer, West, White   +128 more
core   +1 more source

From piles of grains to piles of vortices

, 2021
One of the most thrilling features of Physics is the possibility to establish analogies between apparently distant areas. Here we explain the parallel between a pile of grains interacting mechanically with each other, and a "pile" of superconducting vortices.
openaire   +2 more sources