Results 81 to 90 of about 517,497 (289)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

2-pile Nim with a Restricted Number of Move-size Imitations

open access: yes, 2007
We study a variation of the combinatorial game of 2-pile Nim. Move as in 2-pile Nim but with the following constraint: Suppose the previous player has just removed say $x>0$ tokens from the shorter pile (either pile in case they have the same height ...
Larsson, Urban
core   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Fluorescence decay data analysis correcting for detector pulse pile-up at very high count rates

open access: yes, 2017
Using Time-Correlated Single Photon Counting (TCSPC) for the purpose of fluorescence lifetime measurements is usually limited in speed due to pile-up.
Dowler, Rhys   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

A Nonlinear SW Model for Laterally Loaded Piles in the Proximity of Sandy Slopes with Consideration of Slope Surface Deformation

open access: yesBuildings
This paper develops a nonlinear strain wedge (SW) model for analyzing laterally loaded piles installed in the proximity of sandy slopes, with consideration of slope surface deformation.
Wei Wang, Lingzhi Zhang
doaj   +1 more source

Foundation Technology Development Of Hydraulic Structure On Peat Soil

open access: yesJurnal Teknik Hidraulik, 2018
Many hydraulic structures in Indonesia are built on peat soil, especially in Sumatra, Kalimantan and Papua. This soil has bad geotechnical characteristic for building foundation, because its low of shear strength, high potential of land subsidence and ...
Mahdi Ibrahim Tanjung   +2 more
doaj   +1 more source

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