Results 71 to 80 of about 517,497 (289)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

High count rate {\gamma}-ray spectroscopy with LaBr3:Ce scintillation detectors

, 2012
The applicability of LaBr3:Ce detectors for high count rate {\gamma}-ray spectroscopy is investigated. A 3"x3" LaBr3:Ce detector is used in a test setup with radioactive sources to study the dependence of energy resolution and photo peak efficiency on ...
B. Löher, D. Savran, Devanathan, E. Fiori, Iltis, Kulisek, Kurosawa, M. Miklavec, M. Vencelj, Milbrath, Moses, Moszynski, Moszynski, N. Pietralla, Novak, Quarati, Régis, Smith, van Loef, Vencelj, Zhu   +20 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Change of Scaling and Appearance of Scale-Free Size Distribution in Aggregation Kinetics by Additive Rules

, 2014
The idealized general model of aggregate growth is considered on the basis of the simple additive rules that correspond to one-step aggregation process.
Ananthakrishna, Ben-Naim, Bhat, Chandrasekhar, Corder, Cramer, Cullen, Fokker, Gatsenko, Gatsenko, Gordienko, Gordienko, Gordienko, Gordienko, Hähner, Ispolatov, Kacsuk, Kacsuk, Ke, Kleiser, Knuth, Kolmogorov, Leyvraz, Lifshitz, Lin, Lin, Mandelbrot, Neuhäuser, Planck, Smirnov, Smoluchowski, Stach, Stach, Urbach, van Kampen, Yuri G. Gordienko, Zaiser, Zangwill   +37 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Weronika Wilczyńska, Maciej Mackiewicz, Jarosław Krajka, Komunikacja interkulturowa. Wprowadzenie. Wydawnictwo Uniwersytetu Adama Mickiewicza. Poznań 2019. 685 S.

Polilog: Studia Neofilologiczne, 2023
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Tomasz Róg
doaj  

Vector lattice model for stresses in granular materials

, 2000
A vector lattice model for stresses in granular materials is proposed. A two dimensional pile built by pouring from a point is constructed numerically according to this model.
A. Drescher, B. Miller, C. Eloy, C.-H. Liu, D.C. Hong, D.M. Mueth, F. Cantelaube, F. Radjai, J.-P. Bouchaud, J.E.S. Socolar, J.P. Wittmer, M.L. Nguyen, O. Narayan, Onuttom Narayan, P. Claudin, P. Dantu, R.M. Nedderman, S.N. Coppersmith, T. Travers   +18 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source