Results 61 to 70 of about 132,129 (241)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Development and Testing of an Instrumented Open-Ended Model Pile [PDF]
, 2012 This paper describes the development of a model instrumented open-ended (pipe) pile. The importance of model geometry and separating the shaft, annular and plug load, and horizontal effective stresses is discussed.
Igoe, David +2 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
THE SHEAR BEHAVIOUR OF THE REINFORCED CONCRETE FOUR-PILE CAPS
, 2009 There has been a consistent discrepancy between UK design standards BS5400 and BS8110 in the prediction of the shear capacity of 2-way spanning reinforced concrete pile caps from bending theory-based empirical design formulae.
Cao, Jing
core +1 more source
Międzynarodowy Festiwal Muzyki Religijnej im. ks. Stanisława Ormińskiego w Rumi (20-22.10.2016)
Seminare, 2022 Krzysztof Niegowski
doaj +1 more source
BuildingsThis paper develops a nonlinear strain wedge (SW) model for analyzing laterally loaded piles installed in the proximity of sandy slopes, with consideration of slope surface deformation.
Wei Wang, Lingzhi Zhang
doaj +1 more source
The thermal behaviour of three different auger pressure grouted piles used as heat exchangers [PDF]
, 2014 Three auger pressure grouted (APG) test piles were constructed at a site in Richmond, Texas. The piles were each equipped with two U-loops of heat transfer pipes so that they could function as pile heat exchangers.
Brettmann, T +11 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source