Results 81 to 90 of about 513,449 (250)

Foundation Technology Development Of Hydraulic Structure On Peat Soil

Jurnal Teknik Hidraulik, 2018
Many hydraulic structures in Indonesia are built on peat soil, especially in Sumatra, Kalimantan and Papua. This soil has bad geotechnical characteristic for building foundation, because its low of shear strength, high potential of land subsidence and ...
Mahdi Ibrahim Tanjung, Nurlia Sadikin, Dery Indrawan   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fluorescence decay data analysis correcting for detector pulse pile-up at very high count rates

, 2017
Using Time-Correlated Single Photon Counting (TCSPC) for the purpose of fluorescence lifetime measurements is usually limited in speed due to pile-up.
Dowler, Rhys, Koenig, Marcelle, Patting, Matthias, Reisch, Paja, Sackrow, Marcus, Wahl, Michael   +5 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Nonlinear SW Model for Laterally Loaded Piles in the Proximity of Sandy Slopes with Consideration of Slope Surface Deformation

Buildings
This paper develops a nonlinear strain wedge (SW) model for analyzing laterally loaded piles installed in the proximity of sandy slopes, with consideration of slope surface deformation.
Wei Wang, Lingzhi Zhang
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Internal dynamics of the galaxy cluster Abell 545

, 2011
Diffuse radio emission in galaxy clusters, and their connection with cluster mergers, are still debated. We seek to explore the internal dynamics of the radio halo cluster Abell 545.
Abell, Anders, Ashman, Bacchi, Bardelli, Barrena, Barrena, Barrena, Beers, Beers, Beers, Beers, Beers, Bekki, Bell, Bertin, Binggelli, Bird, Biviano, Bonafede, Boschin, Boschin, Boschin, Boschin, Brunetti, Bullock, Buote, Buote, Böhringer, Carlberg, Cassano, Cassano, Cassano, Cassano, Cassano, Cavaliere, Chilingarian, Chilingarian, D. Eckert, Danese, David, den Hartog, Dolag, Dolag, Donnert, Dressler, Dubinsky, Ellingson, Ensslin, Ensslin, Ensslin, Fadda, Fasano, Ferrari, Ferrari, Ferrari, Finoguenov, Fukugita, Giovannini, Giovannini, Girardi, Girardi, Girardi, Girardi, Girardi, Girardi, Goto, Govoni, Hashimoto, Henriksen, Henry, Hoeft, Kalberla, Kennicutt, Kneib, Landolt, Leccardi, Leccardi, Limber, Lin, Liu, Loeb, M. Girardi, M. Rossetti, Malumuth, Markevitch, Markevitch, Mastropietro, Menci, Merritt, Million, Mushotzky, Navarro, Niederste-Ostholt, Nieto, Okabe, Owers, Pinkney, Pisani, Pisani, Quintana, R. Barrena, Ramella, Ramella, Ricker, Rines, Roettiger, Roettiger, Roettiger, Rossetti, Rudick, S. De Grandi, Salinas, Salinas, Sarazin, Sastry, Schlegel, Schneider, Springel, Struble, Struble, The, Tonry, Tribble, van Dokkum, W. Boschin, Wainer, West, White   +128 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Isostaticity and Mechanical Response of Two-Dimensional Granular Piles

, 2004
We numerically study the static structure and the mechanical response of two-dimensional granular piles. The piles consist of polydisperse disks with and without friction.
Akihiro Kasahara, C. F. Moukarzel, Hiizu Nakanishi   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source